Neurodevelopmental Genomics

在过去的一年里，7500名青年参加了这项研究，并接受了临床和医学访谈以及认知测试，其中750人完成了该项目的神经成像部分。NIMH和宾夕法尼亚大学的团队在诊断措施的开发方面进行了密切合作，并开发了识别有情绪和行为障碍风险的青少年以及一系列医疗条件的算法。目前正在对这一评估进行交叉验证，并在NIMH现场进行更广泛的诊断面谈。 公共卫生影响： 拟议的综合表型将使跨疾病的医学受益，并包括神经行为测量，这将有助于阐明神经精神障碍的具体影响以及其他医学疾病对大脑功能的影响。 未来计划： 这项研究的登记工作应在2011年底前完成，NIMH团队将与宾夕法尼亚大学和CHOP的合作者合作，制定数据分析计划。此外，NIMH正在计划对样本中患有情绪障碍和偏头痛的年轻人进行一些嵌套的病例对照研究。

During the past year, 7,500 youth have been enrolled in the study and undergone the clinical and medical interviews, and cognitive testing, and 750 have completed the neuroimaging component of the project. The NIMH and U Penn teams have worked closely in the development of the diagnostic measures, and in developing algorithms for identification of youth at risk for emotional and behavioral disorders, as well as a range of medical conditions. Cross validation of this assessment with more extensive diagnostic interviews at the NIMH site is now underway. Public Health Impact: The proposed comprehensive phenotyping will benefit medicine across diseases and include neurobehavioral measures, which will help elucidate both specific effects of neuropsychiatric disorders and the impact of other medical disorders on brain function. Future Plans: Enrollment of the study should be completed by the end of 2011, and the NIMH team will work with the U Penn and CHOP collaborators to develop plans for analyses of the data. In addition, NIMH is planning some nested case control studies of youth with mood disorders and migraine in the sample.