Vascular Biology Training Grant

描述（申请人提供）：血管生物学的研究对我们预防、监测和治疗心血管疾病的方式产生了显著的变化。过去的五十年见证了病人护理的转变，预期寿命的增加和血管问题患者生活质量的改善。正是通过对下一代的培训，我们取得了这些成就，正是通过培训，我们将继续在预防和保健方面取得进一步的改进。本申请申请经费用于继续培养血管生物学领域的研究生和博士后。我们特别致力于培养能够：(1)“说”各种语言（代谢组学，病理学，分子生物学，基因组学和生物数学）的科学家，(2)整合信息并思考(3)解决实际临床问题。为了实现这些目标，我们开发了一种多导师的方法，新颖的教学成分，并将互动接触医学纳入培训结构。加州大学洛杉矶分校拥有大量的跨学科研究小组，他们的研究重点是血管生物学。该集团包括27个实验室，目前为124名研究生和博士后提供培训。正是这个社区构成了一个独特的培训计划的支柱，为下一代血管生物学研究者。作为洛杉矶唯一的血管生物学培训基金，也是加州四分之一的血管生物学培训基金，自2002年以来，我们已经培养了28名研究生和博士后。在这个项目中，他们发表了101篇同行评议的出版物，其中9篇已经在全国的工业和大学中发展成为独立的研究小组。此外，与培训计划相关的活动催化了小组之间的互动，加强了合作活动。平均每年有10份同行评议的出版物有两个或更多的实验室参与。每年招收7名博士预科生和3名博士后，每年招收2-3名研究生和1 - 2名博士后。我们的另一个目标是积极寻求和促进未被充分代表的少数群体的培训和参与（自2002年以来，我们有21%的少数群体学员代表）。这个项目的一个重要目标是走在血管生物学教育创新的前沿，强调研究诚信和道德。在当前的更新中，我们提出了几项新策略的实施，以实现这些目标，并进一步提高少数民族的参与和血管研究的培训质量。这个培训项目的成功引起了加州大学洛杉矶分校医学院、文理学院和研究生部的热情，他们都承诺为VBTP开发的活动提供额外的机构支持。

DESCRIPTION (provided by applicant): Research in vascular biology has been responsible for remarkable changes in how we prevent, monitor and treat cardiovascular disease. The last fifty years have witnessed a transformation in patient care, increase in life expectancy and improvement in the quality of lives of those afflicted with vascular problems. It is through training of the next generation that we have made these achievements and it is through training that we will continue to make additional improvements in prevention and health care. The present application request funds to continue the interdisciplinary training of graduate students and post-doctoral fellows in vascular biology. In particular we aim at developing scientists who can: (1) "speak" various languages (metabolomics, pathology, molecular biology, genomics, and biomathematics), (2) integrate information and think towards (3) solving real clinical problems. To achieve these goals we have developed a multi-mentorship approach, novel didactic components and incorporated an interactive exposure to medicine into the structure of the training. UCLA houses a tremendous resource of interdisciplinary groups whose research focuses in vascular biology. The group includes 27 laboratories that currently offer training to 124 graduate students and post-doctoral fellows. It is this community that constitutes the pillars of a unique training program for the next generation of investigators in vascular biology. Being the only Vascular Biology Training grant in Los Angeles and one in four in California, we have trained 28 graduate students and post-doctoral fellows since 2002. These have produced 101 peer-reviewed publications while in the program and 9 have progressed to develop independent research groups in industry and universities across the nation. Furthermore, the activities associated with the training program have catalyzed interactions between groups intensifying collaborative activities. On the average 10 peer reviewed publications show the participation of two or more laboratories each year. Here, we request funding for 7 pre and 3 post-doctoral fellows / year, in which 2-3 new graduate students and either 1 or 2 post-doctoral fellows will enter the program each year. It is also our goal to actively seek and promote training and engagement of underrepresented minority groups (since 2002 we have a 21% minority trainee representation). It is an important objective of this program to be at the forefront of innovation in vascular biology education with strong emphasis in research integrity and ethics. In this current renewal we proposed the implementation of several new strategies to attain these goals and further improve the participation of minorities and the quality of training in vascular research. The success of this training program has engendered enthusiasm by the School of Medicine, College of Letters and Sciences and the Graduate Division at UCLA all of which have committed to provide additional institutional support towards activities developed by the VBTP.