Etiology of Biliary Tract Cancer

该项目包括三项研究：1)上海胆道癌研究，2)国际胆道癌联合会，3)智利胆囊癌研究。这些研究相辅相成，将为胆道癌的病因提供独特的见解。上海的这项研究包括3000多名受试者，其中包括600多名胆道癌患者，900名胆结石患者，以及从人群中随机选择的1000名健康对照组。一个结构化的问卷被用来获得关于流行病学危险因素的信息，包括吸烟、饮酒、饮食、病史和生殖因素。这项研究有很强的生化和分子成分，收集了大量的生物样本，包括血清、DNA、胆结石、胆汁和组织样本。这项国际联合会的研究包括来自12个国家的20项研究，将数据和样本汇集在一起，进行一项足够有力的研究，以检查胆道癌的病因。该联盟的首要任务是进行一项全球遗传研究，以确定遗传易感性在胆道癌中的作用。智利的胆囊癌研究包括一项对100名受试者的初步研究。这项全面的研究将包括来自智利10个地点的4000名胆囊癌患者和4000名对照组。

This project includes three studies: 1) the Shanghai Biliary Tract Cancer Study, 2) The International Biliary Tract Cancer Consortium, and 3) the Chile Gallbladder Cancer Study. These studies complement each other and will provide unique insight into the etiology of biliary tract cancer. The Shanghai Study includes more than 3,000 subjects, including over 600 biliary tract cancer patients, 900 gallstone patients, and 1,000 healthy controls randomly selected from the population. A structured questionnaire was used to elicit information on epidemiologic risk factors, including smoking, drinking, diet, medical history, and reproductive factors. The study had a strong biochemical and molecular component with an extensive collection of biological samples, including serum, DNA, gallstones, bile, and tissue samples. The International Consortium Study includes 20 studies from 12 countries to pool data and samples together for a sufficiently powered study to examine the etiology of biliary tract cancer. The priority of the consortium is to conduct a GWAS to determine the role of genetic susceptibility in biliary tract cancer. The Chile Gallbladder Cancer Study includes a pilot study of 100 subjects. The full-scale study will include 4000 cases of gallbladder cancer and 4000 controls enrolled from 10 locations in Chile.