Midcareer Investigator Award in Patient-Oriented Research

描述(由申请人提供)：这是一份来自威尔康奈尔医学院的马克·拉克斯医学硕士学位的K24指导奖的续签申请，该奖项以患者为导向的老龄化研究。该计划的近期目标是(1)将候选人在第一个周期中创建的成功的导师计划扩展到哥伦比亚大学的受训者，与琳达·弗里德博士合作，在任何受指导者指导的老龄化研究领域(地方计划)，以及(2)为虐待老年人领域的初级调查人员创建一个全国性的导师计划(国家计划)。这两项倡议都源于第一个周期中确定的障碍，这些障碍阻碍了两个特定学员群体的职业发展。就拟议的本地项目而言，哥伦比亚大学享誉世界的老龄研究活动尚未对其老年医学系产生很大影响。在拟议的国家项目中，虐待老年人领域缺乏训练有素的调查人员，他们可以指导下一代研究人员，这是一个令人担忧的问题；拉克斯博士是NIH历史上唯一在该领域拥有RO1的内科科学家，这是K24机制的要求。在第一个K24周期的过程中，希望获得指导的两种类型的学员都会定期与候选人联系；此次续签使这一过程正规化，同时继续为最初计划创造的稳定的潜在指导者池提供服务。第一个周期的显著成就包括：指导了24名各级受训人员，他们与国际和平协会共同撰写了多本出版物，并获得了许多联邦和基金会的赠款；续签了父母RO1--NIA历史上研究养老院住院老人虐待(RREM)的最大金额的赠款；获得了作为受训者资源的另外三笔主要赠款；以及获得或续签了康奈尔大学的几项主要中心赠款(国际和平协会在此协助下)，这些赠款拥有试点方案和其他能够帮助国家和地方受辅导者的资源。其中包括由NIA资助的Roybal Center(由前导师Cary Reid博士领导)、NIMH老年抑郁症中心的续建(由长期合作者George Alexopolous博士领导)和CTSC(由科长Julianne Imperato-McGinley博士领导)。在最初一年，计划的两个分支的不同级别的学员参与了三个试点项目：(1)哥伦比亚老年病学家田丹博士(当地计划)在轮式餐饮接受者中补充维生素D的研究(当地计划)，(2)罗切斯特大学老年精神病学家EJ Santos(国家计划)的关于RREM精神病共同发病率的研究，以及(3)康奈尔大学常驻居民Anthony Rosen(当地计划)对辅助生活设施中的REM的研究。PI已经为每个项目提供了数据集和/或研究资源，象征着后续指导的结构。该申请的另一个优势是来自拉克斯博士的同事珍妮·特雷西博士和她在希伯来养老院的研究小组的共同指导。作为一名心理测量学家和统计学家，特雷西博士在他目前的所有项目中都是一名合作的调查员，并在老龄化研究中指导了200多名个人。K24计划的长期目标是(1)更充分地整合康奈尔大学和哥伦比亚大学以患者为导向的老龄研究，从而激励更多的受训人员选择老龄研究领域的职业，以及(2)建立一支自给自足的研究队伍，他们开展以患者为导向的老年虐待研究。国家和地方项目的首要和最长期的目标是，随着被辅导者承担导师的角色，它们最终是自我维持的，独立于候选人。 与公共卫生相关：威尔·康奈尔医学院的马克·拉克斯博士此次更新K24课程的直接目标是(1)将候选人在第一个周期中创建的成功的导师计划扩展到哥伦比亚大学的受训者，以及(2)为虐待老年人领域的初级调查人员创建一个全国性的导师计划。最初一年提出了三个试点项目，涉及方案两个部门不同级别的受训者。该申请的另一个优势是来自拉克斯博士的同事珍妮·特雷西博士和她在希伯来养老院的研究小组的共同指导。作为一名心理测量学家和统计学家，特雷西博士在他目前的所有项目中都是一名合作的调查员，并在老龄化研究中指导了200多名个人。K24计划的长期目标是(1)更充分地整合康奈尔大学和哥伦比亚大学以患者为导向的老龄研究，从而激励更多的受训人员选择老龄研究领域的职业，以及(2)建立一支自给自足的研究队伍，他们开展以患者为导向的老年虐待研究。国家和地方项目的首要和最长期的目标是，随着被辅导者承担导师的角色，它们最终是自我维持的，独立于候选人。

DESCRIPTION (provided by applicant): This is an application for renewal of a K24 mentoring award in patient oriented research in aging from Mark Lachs MD MPH of the Weill Cornell Medical College. The immediate objectives of the program are (1) to extend the candidate's successful program of mentorship created in the first cycle to trainees at Columbia University in collaboration with Dr. Linda Fried in any mentee-directed area of aging research (the local program), and (2) to create a national mentorship program for junior investigators in the field of elder abuse (the national program). Both initiatives derive from barriers identified in the first cycle which hamper career development of two specific mentee constituencies. In the case of the proposed local program, the world renowned aging research activities of Columbia University have not yet highly impacted its Division of Geriatric Medicine. In the case of the proposed national program, dearth of highly trained investigators in the field of elder abuse who can mentor the next generation of researchers is a dire concern; Dr. Lachs is the only physician-scientist in the history of NIH to hold an RO1 in the field, a requirement of the K24 mechanism. Over the course of the first K24 cycle, the candidate was contacted regularly by trainees of both types desirous of mentorship; this renewal formalizes that process while continuing to serve the steady pool of potential mentees created by the original program. Notable achievements in the first cycle include: the mentorship of 24 trainees at all levels who coauthored multiple publications with the PI and received many federal and foundation grants, renewal of the parent RO1 - the largest elder abuse grant in the history of NIA to study resident to resident elder mistreatment (RREM) in nursing homes, the acquisition of three other major grants to the PI which will serve as a resource for mentees, and the acquisition or renewal of several major center grants at Cornell (with which the PI assisted) that have pilot programs and other resources than can assist mentees nationally and locally. These include an NIA funded Roybal Center (led by former mentee Dr. Cary Reid), renewal of an NIMH Geriatric Depression Center (led by longstanding collaborator Dr. George Alexopolous), and a CTSC (led by fellow Division Chief Dr. Julianne Imperato-McGinley). Three pilot projects involving mentees at different levels in both arms of the program are proposed for the initial year: (1) A study of Vitamin D supplementation in meals on wheels recipients by Columbia geriatrician Dr. Tien Dam (local program), (2) A study of psychiatric co-morbidity in RREM by University of Rochester Geriatric Psychiatrist EJ Santos (national program), and (3) a study of RREM in assisted living facilities by Cornell ED Resident Anthony Rosen (local program). The PI has made data sets and/or research resources available for each project, emblematic how subsequent mentoring will be structured. An additional strength of the application is co-mentorship from Dr. Lachs' colleague Dr. Jeanne Teresi and her research group at the Hebrew Home for the Aged. A psychometrician and statistician, Dr. Teresi is a collaborating investigator all his current projects, and has mentored over 200 individuals in aging research. The Long Term Objectives of the K24 program are (1) to more fully integrate patient oriented research in aging at Cornell and Columbia, thereby inciting more trainees to select careers in aging research, and (2) to create a self-sustaining cadre of researchers who conduct patient oriented research in elder abuse. The overarching and longest term objective for both the national and local programs is that they ultimately be self-sustaining and independent of the candidate, as mentees take on mentor roles. PUBLIC HEALTH RELEVANCE: The immediate objectives of this K24 renewal from Dr. Mark Lachs at Weill Cornell Medical College are (1) to extend the candidate's successful program of mentorship created in the first cycle to trainees at Columbia University and (2) to create a national mentorship program for junior investigators in the field of elder abuse. Three pilot projects involving mentees at different levels in both arms of the program are proposed for the initial year. An additional strength of the application is co-mentorship from Dr. Lachs' colleague Dr. Jeanne Teresi and her research group at the Hebrew Home for the Aged. A psychometrician and statistician, Dr. Teresi is a collaborating investigator all his current projects, and has mentored over 200 individuals in aging research. The Long Term Objectives of the K24 program are (1) to more fully integrate patient oriented research in aging at Cornell and Columbia, thereby inciting more trainees to select careers in aging research, and (2) to create a self-sustaining cadre of researchers who conduct patient oriented research in elder abuse. The overarching and longest term objective for both the national and local programs is that they ultimately be self-sustaining and independent of the candidate, as mentees take on mentor roles.