Developmental Adaptation: Child Health Research Center

描述（由申请人提供）：目前的提案寻求更新耶鲁大学医学院儿科系的耶鲁儿童健康研究职业发展计划（YCHRCDP）。最初作为P30奖从1990年至2000年资助，在过去的19年里，YCHRCDP促进了44名研究儿童疾病基本过程的医生科学家的职业发展。我们的长期目标仍然是通过选择优秀的医生-科学家并为他们的独立研究生涯做好准备，重点是基础科学研究，促进儿童健康研究。 像许多部门没有一个专门的研究基金或私人研究基金会，YCHRCDP的支持一直是至关重要的，必不可少的发展在基础科学研究杰出的教师。同样重要的是要注意，没有其他K12计划可用于耶鲁儿科，支持初级教师，医生科学家在基础科学研究的培训。 反映我们的计划的成功，所有学者的69%（42 YCHRCDP毕业生的72%）已收到NIH的支持，与57%接收“R”，“U”，或“P”赠款。59%的学者（YCHRCDP毕业生的62%）获得了基金会的支持。在当前资助期间获得K奖的学者比例（88%）超过了90-05学者的K奖比例（44%）。 妇女占YCHRCDP学者的41%; 11%的获奖者是代表性不足的少数民族。在耶鲁大学完成K奖的YCHRCDP学者中（19名男性和4名女性），两名女性获得了R-01奖，两人都多次续签。我们的七名毕业生现在是耶鲁大学的高级教师（教授或副教授）。在其他机构的23名YCHRCDP毕业生中，3名是教授，5名是副教授，9名是助理教授，6名是各部门的兼职教师。我们的学者共发表了719篇科学报告。在过去五年中，仅报告就有268份。 玛格丽特·K博士儿科主任Hostetter是本提案的主要研究者（PI）。斯科特博士Riverstan，耶鲁大学儿童健康研究中心（YCHRC），一个独立的儿科研究单位主任，是项目主任（PD）和培训主任（TD）。Alda Tufro博士是儿科肾病科主任，在同行培训方面具有相当的专业知识，他将担任招聘官员（RO）。她还将重点关注妇女和代表性不足的少数民族的招聘计划。 在下一个奖项的任期内，我们将建立在我们的计划的优势和传统，以吸引有才华的医生，并培养这些年轻的科学家，因为他们开发国家认可的，独立的儿童健康基础研究计划。根据RFA，所有学者将有至少75%的时间用于研究，研究活动将在基础科学或具有基础科学成分的转化研究。为了实现这些目标，在应用中我们详细介绍：1.程序管理2.咨询委员会3。4.职业发展规划5。项目评估6.候选人/学者7.制度环境和对方案的承诺8.招聘和保留计划，以提高多样性9。在研究的负责任的行为指示。 总的来说，上述计划将继续和改进我们的传统，培训医生科学家从事基础科学研究，以改善儿童健康。一如以往，我们将在下一个拟议的奖项任期内继续加强YCHRCDP。 公共卫生相关性：目前的提案旨在更新耶鲁大学医学院儿科系的耶鲁儿童健康研究职业发展计划（YCHRCDP）。在过去的19年里，YCHRCDP促进了44名研究儿童疾病基本过程的医生-科学家的职业发展。YCHRCDP提供基础科学研究方面的培训，具有强大的实验室和教学组成部分。

DESCRIPTION (provided by applicant): The current proposal seeks renewal of the Yale Child Health Research Career Development Program (YCHRCDP) in the Department of Pediatrics at Yale University School of Medicine. Initially funded as a P30 award from 1990-2000, over the past 19 years the YCHRCDP has fostered the career development of 44 physician-scientists studying fundamental processes of childhood disease. Our long-term goal continues to be the advancement of research in child health by selecting outstanding physician-scientists and preparing them for independent research careers, focusing on basic science research. Like many departments without a dedicated research endowment or a private research foundation, the support of the YCHRCDP has been critical and essential to developing a faculty distinguished in basic scientific investigation. It is also important to note that no other K12 programs are available to Yale Pediatrics that support junior faculty, physician-scientist training in basic science research. Reflecting the success of our program, 69% of all Scholars (72% of the 42 YCHRCDP graduates) have received NIH support, with 57% receiving 'R', 'U', or 'P' grants. 59% of all Scholars (62% of YCHRCDP graduates) have received foundation support. The percentage of Scholars receiving K awards during the current funding period (88%) exceeds the K award percentage of Scholars from 90-05 (44%). Women comprise 41% of YCHRCDP Scholars; 11% of awardees are underrepresented minorities. Of those YCHRCDP Scholars who have completed K awards at Yale (19 males and 4 females), two females attained R-01 awards and both have renewed multiple times. Seven of our graduates are now senior faculty members (Professor or Associate Professor) at Yale. Of the 23 YCHRCDP graduates at other institutions, 3 are Professors, 5 are Associate Professors, 9 are Assistant Professors, and 6 are adjunct faculty in various departments. Collectively our scholars have published 719 scientific reports. Over the past 5 years, there have been 268 reports alone. Dr. Margaret K. Hostetter, Chair of Pediatrics, is the Principal Investigator (PI) of this proposal. Dr. Scott Rivkees, Director of the Yale Child Health Research Center (YCHRC), a free- standing pediatric research unit, is the Program Director (PD) and Training Director (TD). Dr. Alda Tufro, who is Chief of Pediatric Nephrology and has considerable expertise in fellow training, will be the recruiting officer (RO). She will also focus on the recruitment of women and underrepresented minorities to the program. Over the next term of award, we will build on the strengths and traditions of our program to attract talented physicians and to nurture these young scientists as they develop nationally recognized, independent basic research programs in child health. Per the RFA, all Scholars will have at least 75% of their time devoted to research, and research activities will be in basic science or translational research with a basic science component. To achieve these goals, in the application we detail: 1. Program Administration 2. Advisory Boards 3. Program Faculty 4. Proposed Career Development Plan 5. Program Evaluation 6. Candidates/ Scholars 7. Institutional Environment and Commitment to the Program 8. Recruitment and Retention Plan to Enhance Diversity 9. Instruction in the Responsible Conduct of Research. Collectively, the above programs will continue and improve upon our tradition of training physician scientists for careers in basic science research for the betterment of child health. As in the past, we will continue to enhance the YCHRCDP over the next proposed term of the award. PUBLIC HEALTH RELEVANCE: The current proposal seeks renewal of the Yale Child Health Research Career Development Program (YCHRCDP) in the Department of Pediatrics at Yale University School of Medicine. Over the past 19 years the YCHRCDP has fostered the career development of 44 physician-scientists studying fundamental processes of childhood disease. The YCHRCDP provides training in basic science research with strong laboratory and didactic components.