GENETICS OF REPRODUCTIVE SENESCENCE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该方案的目的是建立一个模型系统来研究生殖衰老的遗传基础。该项目将研究一个由500只自然衰老的成年狒狒组成的纯种群体。通过观察来监测繁殖周期，动物在月经周期的第5天和第25天流血。这些数据和分析将确定导致衰老生殖指数变化的人类遗传区域。该菌落将为衰老病理和衰老基因表达谱提供广泛的资源。结合了老化狒狒的规模、经济性、实验环境、谱系和标记集，为我们提供了前所未有的资源来促进我们对人类衰老和健康的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.