HYPOTHALAMIC RESPONSE TO HYPERINSULINEMIC-EUGLYCEMIC CLAMP IN BABOONS BY FMRI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是更好地了解局部脑血流量（CBF）的变化与葡萄糖推注。最近的研究表明，中枢神经系统（CNS）失调可能在代谢性疾病如2型糖尿病、肥胖和心血管疾病的发展中起重要作用。然而，确切的潜在机制尚不清楚。功能性磁共振成像（fMRI）技术已经确定下丘脑作为能量相关信号整合的部位。例如，在糖尿病患者中观察到下丘脑对血糖状态变化的延迟反应。因此，这项研究将提供深入了解下丘脑，以及其他大脑区域的反应，以葡萄糖输注在肥胖和正常体重的狒狒。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study is to get a better understanding of regional changes in cerebral blood flow (CBF) with infusion of a bolus of glucose. Recent studies have shown that central nervous system (CNS) dysregulation may play a major role in the development of metabolic diseases such as type 2 diabetes, obesity and cardiovascular disease. The exact underlying mechanisms are however, not clearly known. Functional magnetic research imaging (fMRI) techniques have identified the hypothalamus as the site of integration of energy-related signals. For example a delayed hypothalamic response to changes in glycemic state has been observed in diabetic patients. Thus this study will provide insight into the response of the hypothalamus, as well as, other brain regions to a glucose infusion in obese and normal weight baboons.