OFFSPRING POSTNATAL CARDIOVASCULAR HEALTH

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项先导性研究的目的是确定血清指标(Hb1Ac和胆固醇)、形态测量指标(体重、区域脂肪分布)和心肾功能(心率、血压、尿量和成分)以及分子遗传学指标(肝脏和肾脏转录组表达)对怀孕期间饮食中脂肪、胆固醇、碳水化合物和盐的反应(母亲营养减少，MNR)是否表明MNR的持续影响，并建议为血脂异常、高血压和/或糖尿病制定计划。我们已经展示了对出生后胆固醇水平的影响，我们将调查受影响的系统，为提交R01‘S未来的NIH R01资金做准备。该项目的最终目标将是利用狒狒胎儿研究和出生后研究的信息，开发出生后从缺陷的胎儿环境中恢复的策略，以将成年人类后代患心血管疾病的风险降至最低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this pilot study is to determine if response of serum measures (Hb1Ac and cholesterol), morphometric measures (body weight, regional fat distribution) and cardio-renal function (heart rate, blood pressure, urine production and composition) and molecular genetic measures (liver and kidney transcriptome expression) to dietary fat, cholesterol, carbohydrate and salt in offspring of mothers fed a 30% reduced diet during pregnancy (maternal nutrient reduction, MNR) offspring indicate persistent effects of MNR and suggest programming for dyslipidemia, hypertension, and/or diabetes. We have already shown effects on post-natal cholesterol levels and we will investigate the systems impacted in preparation for submission of R01's for future NIH R01 funding. The ultimate goal of this project will be to use information from baboon fetal studies and postnatal studies to develop strategies for recuperation from the deficient fetal environment postnatally to minimize risk of cardiovascular disease in the adult human offspring.