COBRE: MUSC: CORE C: CLINICAL RESOURCES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 子项目说明具体目标： + 为有兴趣在MUSC进行临床口腔健康研究的研究人员提供空间和支持; + 让更多的牙科医学院（CDM）教师参与临床和转化研究; + 通过以社区为基础的研究来刺激新的研究发现，从而促进新的研究成果的翻译和采用到社区环境中。 目标 + 提供门诊牙科诊所研究能力，以支持所有大学项目; + 根据不同临床研究方案的要求收集人口统计数据和其他数据; + 根据不同临床研究方案的要求，提供校准的牙科检查和牙科护理服务; + 根据特定临床研究方案的要求，收集和输入口腔健康评估数据; + 收集、处理和分发生物样本供实验室分析; + 协助口腔健康研究者进行临床/ IRB方案制定、参与者招募、数据收集、数据分析、手稿/基金准备; + 通过月度会议确保项目合作伙伴之间的协调; + 参与学术社区合作，改变口腔保健和消除我们社区的口腔健康差距; + 通过将发现转化为社区服务，改善南卡罗来纳州人口的口腔健康状况; + 建立机制，以维持社区倡议的进展。 背景  的核心适用性相关 核心C的目标是以具有成本效益的方式促进临床和转化口腔健康研究，从而有助于加强临床和转化科学的学科。 为了实现这一目标，核心C提供必要的临床专业知识，以实施不同的研究方案;促进临床研究人员的拨款申请过程;并指导临床研究人员进行临床研究设计和方案制定。 核心C已经建立了第二个位置，在5楼的詹姆斯B。爱德华CDM，以及维护一个在MUSC临床和转化研究中心（CTRC），允许核心支持跨学科的研究项目。 清洁发展机制与两个当地社区外展牙科诊所签署了正式协议，即约翰斯岛的慈悲圣母外展社区牙科诊所和芒特普莱森特的库珀社区外展牙科诊所东部，可用作场外设施，促进患者/参与者招募和社区参与。 临床核心与现有的MUSC“海岛家庭项目理事会”合作，提高生活在美国东南部沿海地区沿着的非洲裔美国人的口腔健康研究项目的可信度和可及性。非洲裔美国人古拉人是西非种植水稻的非洲奴隶的直系后裔。Gullah指的是几件事：语言，人和文化。 这一外联活动以及与海岛家庭项目理事会的伙伴关系对参与的双方都是有益的经验。 我们直接从社区了解他们的需求以及医疗中心和社区之间存在的障碍。 南卡罗来纳州的非洲裔美国人占我们州人口的33%，而全国人口占12%。 在这些妇女中发病率过高的疾病是癌症（包括口腔癌和咽癌）、糖尿病、牙周病、高血压、中风、药物滥用、抑郁症、肥胖症、不良妊娠结局和这些疾病的相关并发症。 《美国口腔健康：2000年外科医生报告》中报告的数据描述了一种无声的口腔疾病流行病，不成比例地影响着美国的穷人和少数民族人口。值得注意的是，多项研究发现口腔疾病与全身性疾病之间存在关联。 该核心支持旨在从口腔健康角度描述这一独特和历史上孤立的人群的项目，评估龋齿、牙周病、软组织病变和口腔癌的患病率。核心C还支持评估整体牙科需求和特定人群口腔保健障碍的项目，指导文化敏感的社区临床项目的设计。 为了实现其支持跨学科，以社区为基础的口腔健康研究的目的，核心C与现有的MUSC和社区资源，如：项目SUGAR社区合作伙伴计划; MUSCLE（MUSC红斑狼疮）研究小组;医学院（COM）内分泌学、糖尿病和医学遗传学系; COM流变学和免疫学系;好莱坞，南卡罗来纳州市长办公室;我们的慈悲社区外展诊所的夫人; MUSC中心社区卫生伙伴关系（CCHP）; CCHP社区卫生学者计划; MUSC霍林斯癌症中心; MUSC护理学院;和NCRR的CTSA资助的南卡罗来纳州临床和转化研究所（SCTR）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SUBPROJECT DESCRIPTION SPECIFIC AIMS: + To provide space and support for researchers interested in conducting clinical oral health research at MUSC; + To engage more College of Dental Medicine (CDM) faculty members in clinical and translational research; + To stimulate new research discoveries through community-based research, therefore, facilitating the translation and adoption of new research findings into the community settings. OBJECTIVES + To provide an outpatient dental clinic research capacity to support all university projects; + To collect demographic and other data as required by the different clinical research protocols; + To provide calibrated dental examination and dental care delivery as required by the different clinical research protocols; + To collect and enter oral health assessment data as requested by specific clinical research protocols; + To collect, process and distribute biological samples for laboratory analysis; + Assist oral health investigators with clinical / IRB protocol development, participant recruitment, data collection, data analysis, manuscript / grant preparations; + To ensure coordination between program partners through monthly meetings; + To engage academic-community partnerships, transforming oral health care and eliminating oral health disparities in our communities; + To improve the oral health outcomes of the population of South Carolina through discoveries translated into community service; + To establish mechanisms to sustain the progress of community-based initiatives. BACKGROUND  CORE RELEVANCE The Core C goal is to foster clinical and translational oral health research in a cost effective manner, therefore helping to strength the discipline of clinical and translational science. To accomplish this, Core C provides the necessary clinical expertise to implement different research protocols; facilitates grant application process for clinical investigators; and mentors clinical investigators in clinical study design and protocol development. Core C has established a second location, on the 5th floor of the James B. Edward CDM, as well as maintained the one within the MUSC Clinical and translational Research Center (CTRC), allowing the core to support interdisciplinary research projects. The CDM has formal agreements signed with two local community outreach dental clinics, the Our Lady of Mercy Outreach Community Dental Clinical, in Johns Island and the East of the Cooper Community Outreach Dental Clinical, in Mount Pleasant, that can be used as off-site facilities, facilitating patient/participant recruitment and community engagement. The Clinical Core collaborates with the existing MUSC "Sea Island Families Project Council", improving credibility and access of oral health research projects among African-Americans living along the Southeastern U.S. sea costal regions. The African American Gullah population are a direct descendant population of rice plantation enslaved Africans from West Africa. Gullah refers to several things: language, people, and a culture. This outreach activity and the partnership with the Sea Island Families Project Council has been a beneficial experience for both parts involved. We have learned directly from the community about their needs as well as the barriers that exist between a medical center and the community. The African Americans in South Carolina comprise ~33% of our state's population compared to ~12% nationally. Diseases that are disproportionately prevalent among them are cancers (including oral and pharyngeal), diabetes, periodontal disease, hypertension, stroke, substance abuse, depression, obesity, adverse pregnancy outcomes and the related complications of these disorders. Data reported in Oral Health in America: A Report of the Surgeon General, 2000 describe a silent epidemic of oral disease disproportionately affecting the nation's poor and minority populations. It is noteworthy that multiple studies find an association between oral and systemic diseases. The Core supports projects aiming to characterize this unique and historically isolated population from an oral health perspective, by assessing the prevalence of caries, periodontal disease, soft tissue lesions and oral cancer. Core C also supports projects assessing the overall dental needs and the barriers to oral health care specific to this population, guiding the design of culture sensitive community-based clinical projects. To fulfill its purpose of supporting interdisciplinary, community-based oral health research, Core C has developed substantial partnerships with existing MUSC and community resources, such as: Project SUGAR Community Partnership Program; MUSCLE (MUSC Lupus Erythematosus) Research Group; College of Medicine (COM) Division of Endocrinology, Diabetes and Medical Genetics; COM Division of Rheumatology and Immunology; Hollywood, SC mayor's office; Our Lady of Mercy Community Outreach Clinic; MUSC Center for Community Health Partnerships (CCHP); CCHP Community-Engaged Scholars Program; MUSC Hollings Cancer Center; MUSC College of Nursing; and the NCRR's CTSA funded South Carolina Clinical and Translational Research Institute (SCTR).