COBRE: MUSC: CORE B: BIOSTATISTICS CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 生物统计学核心是支持MUSC口腔健康研究人员的起步、成长和维持的基础设施的关键组成部分。核心B活动侧重于以下四个目标： (1)统计合作，包括协助设计新的研究；编写赠款提案；校准研究的随机化和盲目化计划；统计分析和相关报告；协助将统计解释纳入科学结论和出版物； (2)数据管理，包括设计、实施和维护数据库、数据输入和将数据从远程地点转移到MUSC的方法；数据质量保证方案；记录数据文件以便于今后查阅；数据安全和数据文件存档以供长期储存； (3)为所有Cobre研究人员提供生物统计学方法指导，包括与口腔健康研究有关的初级生物统计师和方法的指导；以及 (4)根据具体项目的需要开发新的生物统计方法，并将最新的生物统计方法转让给口腔健康研究界。 此外，Core B还为Cobre调查人员建立和维护了科学计算基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Biostatistics Core is a critical component of the infrastructure supporting the initiation, growth and sustenance of oral health researchers at MUSC. Core B activities are focused on the following four aims: (1) statistical collaboration, including assistance with design of new studies; preparation of grant proposals; randomization and blinding schemes for calibration studies; statistical analyses and associated reports; and assistance in the integration of statistical interpretations into scientific conclusions and publications; (2) data management, including design, implementation and maintenance of databases, data entry and methods for data transfer from remote sites to MUSC; a program of data quality assurance; documentation of data files for ease of accessibility in the future; and data security and archiving of data files for long-term storage; (3) mentoring in biostatistical methods for all COBRE investigators, including mentoring of a junior biostatistician in collaboration and methods relevant to oral health research; and (4) development of new biostatistical methods as needed for specific projects and transfer of recent biostatistical methods to the oral health research community. Additionally, Core B established and maintains a scientific computing infrastructure for COBRE investigators.