COBRE: LSU: ADMIN, MENTOR, RECRUIT & EVAL CORE: STROKE, NEURODEGEN DIS, BEHAV

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 行政、指导、招聘和评价核心将对科布雷的所有活动进行集中协调和监督。LSUHSC领导着路易斯安那州四个机构在神经科学研究方面的合作伙伴关系。项目主任和知名科学家是精选的、非常有前途的初级教员的导师，他们执行四个研究项目，这些项目旨在指导建立新的全国有竞争力的研究的共同目标。科学的焦点集中在神经生物学的一个中心问题上：了解突触可塑性和神经元存活的细胞和分子基础，对于阐明中风、神经创伤和神经退行性疾病等神经疾病的病理生理学至关重要。这个多学科的项目涉及细胞神经生理学、分子生物学和行为神经科学。为了支持Cobre项目，核心资源包括成像设施、脂质信使的神经化学和分子神经生物学。为期2至5年的招聘计划通过积极吸引新的研究人员，使合作机构进一步受益，这些研究人员将在知名神经科学家的指导下工作，作为导师。所需的行政核心资金相对较少。实现这些目标的具体目标是1)通过研究项目促进教师发展；2)通过招聘、启动、指导和留住新教师，进一步培养一大批有竞争力的外部资助研究人员；3)通过在LSUHSC开发三个核心研究模块，加强对扩大路易斯安那州神经科学能力至关重要的基础设施；4)提供科学和赠款指导，并加强促进互动的支持网络；以及5)实施中期和结果评估，以使Cobre计划保持在正轨上。这一伙伴关系建立在现有专业知识的基础上，我们坚定地决定在路易斯安那州建立一个在科学上成功的神经科学联盟。四名目标教员和四名即将招聘的教员是实现这些目标的关键基石。核心资源对该联盟的整体成功至关重要，不仅是在神经科学方面，而且在所有生物医学科学方面。指导初级教员的计划和招聘计划将确保路易斯安那州源源不断地涌现出新的具有全国竞争力的神经科学家。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Administrative, Mentoring, Recruitment and Evaluation Core will provide centralized coordination and oversight to all the activities of this COBRE. The LSUHSC leads a partnership of four Louisiana institutions in a COBRE on neuroscience research. The Program Director and established scientists are mentors to selected, highly promising junior faculty who execute four research projects that have been designed for the common goal of mentoring to build new nationally competitive research. The scientific focus is on a central issue of neurobiology: to understand the cellular and molecular basis of synaptic plasticity and neuronal survival critical to clarify the pathophysiology of neurological disorders such as stroke, neural trauma and neurodegenerative diseases. This multidisciplinary program involves cellular neurophysiology, molecular biology and behavioral neuroscience. To support the COBRE projects, core resources include facilities for imaging, neurochemistry of lipid messengers and molecular neurobiology. A recruitment plan for years 2 to 5 further benefits the collaborating institutions by actively attracting new research faculty who will work under the guidance of established neuroscientists as mentors. A relatively small administrative core funding is requested. The specific aims to attain these objectives are 1) to promote faculty development through research projects; 2) to further develop a critical mass of competitive extramurally funded investigators by the recruitment, start up, mentoring and retention of new faculty members; 3) to enhance the infrastructure critical for expanding neuroscience capability in Louisiana by developing three core research modules at LSUHSC; 4) to provide scientific and grantsmanship mentoring and strengthen the support network that promotes interactions; and 5) to implement interim and outcome evaluations so as to keep this COBRE program on track. This partnership rests on existing expertise and in our firm decision to build a scientifically successful neuroscience alliance in Louisiana. The four target faculty and the four to-be-recruited faculty are the critical building blocks to achieve these goals. The core resources are vital to the overall success of this consortium, not only in neuroscience but in all the biomedical sciences. The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana.