HYPERPOLARIZED GAS IMAGING AT THE DIFFUSION LIMIT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们将开发多通道(1H/3He和129Xe/1H)3D径向编码，以扩散和磁化率极限所构成的空间分辨率对小鼠肺进行活体成像。 为了实现这一目标，我们将整合三项紧密结合的技术改进： --我们将在我们的成像链中集成一个双通道射频线圈，以便在85兆赫和兆赫同时采集，以提高灵敏度。 -我们将安装新的更高强度梯度(400 Mt/m)，以减少扩散的影响。 --我们将优化3D(双通道)径向采集序列，以限制敏感性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We will develop multi-channel (1H/3He and 129Xe/1H) 3D radial encoding for in vivo imaging of the mouse lung at the spatial resolution posed by diffusion and susceptibility limits. To achieve this aim, we will integrate three tightly coupled improvements in technology: -- We will integrate a dual-channel rf coil into our imaging chain for simultaneous acquisition at 85 and 64 MHz to improve the sensitivity. -- We will install new higher strength gradients (400 mT/m) to reduce the impact of diffusion. -- We will optimize a 3D (dual-channel) radial acquisition sequence to limit the effects of susceptibility.