NOVEL TECHNIQUES FOR DYNAMIC CONTRAST ENHANCED MRI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 动态对比MRI正广泛应用于肿瘤成像研究。应用包括表征病变为良性或恶性和评估治疗反应。人们特别感兴趣的是使用动态对比增强（DCE）MRI来早期检测靶向人类受试者和动物模型中血管生成的反应疗法。我们已经开发了一种交错反投影（或径向）成像技术，允许采集一系列具有高时间和空间分辨率（动态KWIC）的图像，我们将继续改进DCE-MRI策略，以提高图像质量并提高灌注测量的准确性。该项目的长期目标是加强对新疗法的评估，提高DCE-MRI的诊断价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dynamic contrast MRI is being widely applied to studies of cancer imaging. Applications include characterization of lesions as benign or malignant and assessing therapeutic response. There is particular interest in the use of dynamic contrast enhanced (DCE) MRI for the early detection of response therapies that target angiogenesis in human subjects and animal models. We have developed an interleaved backprojection (or radial) imaging technique that allows acquisition of a series of images with both high temporal and spatial resolutions (dynamic KWIC), and we continue to improve the DCE-MRI strategy to improve the image quality and enhance the accuracy of perfusion measurements. The long-term goal of this project is to enhance the assessment of novel therapies and improve the diagnostic value of DCE-MRI.