T1? IMAGING OF MYOCARDIAL INFARCTION IN HUMANS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目的目标是开发内源性对比磁共振成像的方法，以提高对心肌梗死后心力衰竭的理解，间接将内源性对比与左心室重构的分子机制相关联，并取代现有的肾衰竭患者的外源性对比磁共振成像。左心室重构导致心脏的大小、厚度和几何形状的长期变化，这对心输出量和患者预后产生不利影响。用于检测长期梗死变化的两种常规MRI方法是T2加权成像和延迟对比增强（DCE-MRI）磁共振成像，然而，后者与额外的成本相关，并且可能损害患者的安全性和舒适度。我们假设可以通过3 T体内自旋锁定等内源性对比方法实现高内源性对比度，并且通过梗死范围测量，梗死形态测量与VCE相当。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to develop methods of endogenous contrast magnetic resonance imaging to improve understanding of post-myocardial infarction heart failure, indirectly correlate endogenous contrast with molecular mechanisms of left ventricular remodeling and supplant existing exogenous contrast magnetic resonance imaging for patients in renal failure. Left ventricular remodeling results in long-term changes to the size, thickness and geometry of the heart, which adversely affects cardiac output and patient prognosis. Two conventional MRI methods for detection of long-term infarct changes are T2-weighted imaging and delayed, contrast enhanced (DCE-MRI) magnetic resonance imaging, however, the latter is associated with additional costs and can potentially compromise patient safety and comfort. We hypothesize that high, endogenous contrast can be achieved by endogenous contrast methods like spin locking in vivo at 3 T and that infarct morphometry is comparable to DCE by infarct extent measurement.