MUSSEL ADHESIVE PROTEINS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 提高聚合反应的生物粘附性的一种策略是引入已知具有粘附性的生物部分--自然界中的粘附性。众所周知，海洋贻贝分泌独特的黏附蛋白(贻贝黏附蛋白，MAP)，这些黏附蛋白质能与各种水下表面形成强大的防潮结合。MAP的一个有趣特征是存在3-(3，4-二羟基苯基)-L-丙氨酸(DOPA)，这是一种被认为与MAP的粘连和交联特性有关的氨基酸。邻苯二酚形式的DOPA被认为是导致表面附着的原因，而氧化的邻苯二酚形式则是导致MAP交联的原因。我们的研究集中在多巴的这种交联化反应，以创造独特的水凝胶，具有医疗粘合剂的价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. One strategy for enhancing the bioadhesive characteristics of polymersis to introduce biological moieties that are known to possess adhesiveproperties in nature. It is known that marine mussels secreteunique adhesive proteins (mussel adhesive proteins, MAPs) that form strongmoisture-resistant bonds to a variety of underwater surfaces. One interestingfeature of MAPs is the presence of 3-(3,4-dihydroxyphenyl)-L-alanine(DOPA), an amino acid which is believed to be responsible for both adhesionand cross-linking characteristics of MAPs. The catechol form of DOPA isthought to be responsible for adhesion to surfaces, while the oxidized o-quinoneform is responsible for cross-linking of the MAPs. Our research focuses on this crosslinking reaction of DOPA to creative unique hydrogels that have value as medical adhesives.