BARMAH FOREST VIRUS (BFV)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 巴马森林病毒（Barmah Forest virus，BFV）是披膜病毒科甲病毒属的一种虫媒病毒。目前，它是内源性的澳大利亚，它是病毒性关节炎和关节痛的主要原因之一。其临床表现与辛德毕斯和罗斯河病毒相似，但血清学不同，与辛德毕斯血凝素抗体交叉反应弱，与塞姆利基森林病毒核衣壳蛋白单克隆抗体无反应。我们对BFV的研究包括制作亚纳米分辨率的病毒3D图谱，并调查其与其他甲病毒的结构相似性和差异。由于BFV是一种甲病毒，我们希望该病毒的高分辨率图谱将有助于其他甲病毒的研究，更普遍的是，包膜病毒。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Barmah Forest virus (BFV) is an arbovirus, member of Alphavirus genus of Togaviridae family. Currently, it is endogenous to Australia where it is one of the leading causes of viral arthritis and arthalgia. It is similar to Sindbis and Ross River virus in its clinical manifestations but is serologically different, with weak cross-reactivity to antibodies against Sindbis hemagglutinin and no reaction with monoclonal antibodies against Semliki Forest virus nucleocapsid protein. Our studies of BFV include production of subnanometer resolution 3D map of the virus and investigation into its structural similarities and differences with other alphaviruses. Since BFV is an alphavirus, we hope the high resolution map of the virus would be useful for studies of other alphaviruses, and, more generally, enveloped viruses.