DEVELOPMENTS FOR SINGLE CRYSTAL XAS INSTRUMENTATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 单晶X射线吸收光谱允许连续测量X射线衍射和X射线吸收数据，使实验人员能够同时获得蛋白质或小分子活性中心的全局结构和原子级局部结构信息。2010年期间对单晶XAS的设置进行了增量更改，特别是减少散射的方法，以便能够测量较小的晶体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Single crystal x-ray absorption spectroscopy allows for the sequential measurement of x-ray diffraction and x-ray absorption data enabling the experimenter to obtain simultaneous global structure and atomic-level local structure information of a protein or small molecule active site. Incremental changes were made to the single crystal XAS setup during 2010, in particular approaches to minimize scatter to enable the measurement of smaller crystals.