STRUCT STUD OF MEMBRANE & PROTEIN COMPLEX INVOLVED IN ENERGY CONV & SIGNAL

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 细胞色素bc 1复合物是药物（如阿托伐醌，白念珠菌内酯）和农业杀真菌剂（azoxystrobind，kresoxym-methyl，famoxadone）的重要靶标。这些化学物质以可能反映用于门控电子转移的催化开关机制的方式影响Rieske铁硫蛋白（RISP）在晶体中的位置。我们正在研究这些抑制剂的结合模式，以阐明酶的作用机制，并开发更好的抑制剂。 一些时间也将用于测试与呼吸复合体成熟、先天免疫和信号转导相关的项目中的新晶体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The cytochrome bc1 complex is an important target for pharmaceutical (e.g. Atovaquone, Leucascandrolide) and agricultural fungicides (azoxystrobind, kresoxym-methyl, famoxadone) These chemical affect the position of the Rieske iron-sulfur protein (RISP) in the crystals in a fashion that may reflect a catalytic switch mechanism for gating the electron transfer. We are studying the mode of binding of these inhibitors to elucidate the mechanism of the enzyme and to enable development of better inhibitors. Some of the time will also be used for testing new crstals from projects related to respiratory complex maturation, innate immunity, and signal transduction.