STRUCTURAL BIOLOGY OF ENERGY-TRANSDUCING MEMBRANE PROTEINS

能量转导膜蛋白的结构生物学

• 批准号: 8171504
• 负责人: EDWARD Alan BERRY
• 金额: $ 4.28万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171504
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Data; Deposition; Funding; Grant; Home environment; Institution; Iron; Membrane Proteins; Nature; Proteins; Research; Research Personnel; Resolution; Resources; Source; Structure; Sulfur; Synchrotrons; Testing; United States National Institutes of Health; improved; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to test a hypothesis about mobility of the iron-sulfur domain n this protein, we need to collect data from a crystal form in which this domain is trapped immobile by crystal contacts. This is the case in the P6522 crystals which we used previously (Zhang et al. Nature 1998 392: 677-84; also structure 1BE3 deposited by another group. Now we are trying to grow these crystals again and improve the resolution, but the home source is out of commission so we need to screen as well as collect at the synchrotron.

这个子项目是众多研究子项目之一