UNDERSTANDING RNA DIRECTED RNA POLYMERASES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 RNA依赖性RNA聚合酶通常存在于从丙型肝炎（HCV）到普通感冒（鼻病毒）的致病病毒中。 RNA依赖性RNA聚合酶的结构显示出显著的保守性，表现出具有三个主要结构域（手掌、手指和拇指）的整体折叠，如右手一样排列。 这种强的结构保守性使得病毒RNA依赖性RNA聚合酶成为抗病毒化合物的引人注目的靶标。 我们的研究重点是了解RNA依赖的RNA聚合酶如何发挥作用，以合理开发广泛作用的抗病毒化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. RNA-dependent RNA polymerases are commonly found in pathogenic viruses from Hepatitis C (HCV) to the common cold (rhinovirus). Structures of RNA-dependent RNA polymerases show a remarkable amount of conservation exhibiting an overall fold with three major domains (palm, fingers and thumb) arranged like a right hand. This strong structural conservation makes viral RNA-dependent RNA polymerases a compelling target for antiviral compounds. Our research focuses on understanding how RNA-dependent RNA polymerases function in order to rationally develop broad acting antiviral compounds.