BIOINFORMATICS FOR GLYCOMICS CHALLENGE PROJECT FOR FIRST YEAR GRADUATE STUDENTS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 波士顿大学生物信息学项目要求一年级研究生参加为期一年的“挑战项目”，在这些项目中，他们与学术合作者一起研究重大的生物信息学问题。 在2009-10学年，Zaia教授参与了这样一个项目，该项目涉及开发用于糖组学液相色谱质谱数据集目标分析的软件。 这一努力产生了一个名为Manatee的程序，用于LC/MS数据集的目标分析（1）。 在2010-11年，这项工作继续与第二队的一年级研究生。 这些学生正在开发一种对聚糖上获得的去卷积LC/MS数据进行评分的方法。 这种评分将对去卷积的MS信号进行排序，以促进聚糖组成的分配。 此外，该软件将提供一种生成目标聚糖组成列表的方法，以便于解释，并将包括用户友好的可视化界面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Boston University Bioinformatics Program requires first year graduate students to participate in year-long "Challenge Projects" in which they work with academic collaborators on significant bioinformatics problems. During the 2009-10 academic year, Prof. Zaia participated in such a project concerning developing software for targeted analysis of glycomics liquid chromatography mass spectrometry data sets. This effort resulted in a program called Manatee for targeted analysis of LC/MS data sets (1). During the 2010-11 year, the work was continued with a second team of first year graduate students. These students are developing a means of scoring deconvoluted LC/MS data acquired on glycans. Such scoring will rank deconvoluted MS signals to facilitate assignment of glycan compositions. In addition, the software will provide a means of generating targeted glycan composition lists to facilitate interpretation and will include a user friendly visual interface.