NON-INVASIVE QUANTITATION OF CELLU & BIOCHEM CHANGES IN SPINOCEREBELLAR ATAXIAS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 (与芝加哥大学神经病学和Christopher Gomez博士合作，神经病学，由R21 NS056172，慈善基金和Bob Allison共济失调研究中心，Pi Oz支持)：在这个项目中，我们研究了与脊髓小脑性共济失调(SCA)神经变性相关的神经化学改变。其目标是建立和验证与神经退行性变相关的多种细胞和生化事件的标记，如神经元死亡、胶质增生和氧化应激。到目前为止，我们已经扫描了SCA1、SCA2、SCA6、Friedreich‘s共济失调、小脑多系统萎缩和共济失调伴动眼运动性失用的2型患者，以及年龄匹配的健康对照组。我们通过高场核磁共振波谱(MRS)检测了共济失调患者神经化学特征的变化，并发现这些变化是不同共济失调亚型所特有的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. (in collaboration with Dr.s Khalaf Bushara, Neurology and Christopher Gomez, University of Chicago, Neurology, supported by R21 NS056172, philanthropic funds and Bob Allison Ataxia Research Center, PI Oz): In this project we study the neurochemical alterations that are associated with neurodegeneration in spinocerebellar ataxias (SCAs). The goal is to establish and validate markers of multiple cellular and biochemical events associated with neurodegeneration, such as neuronal death, gliosis and oxidative stress. We have so far scanned patients with SCA1, SCA2, SCA6, Friedreich's ataxia, cerebellar multiple system atrophy and ataxia with oculomotor apraxia type 2, as well as age-matched healthy controls. We have detected alterations in the neurochemical profile in ataxias by high field nuclear magnetic resonance spectroscopy (MRS) and found that these are specific for different ataxia subtypes.