A QUANTITATIVE COMPARISON OF NIRS AND FMRI ACROSS MULTIPLE COGNITIVE TASKS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 近红外光谱（NIRS）是一种越来越受欢迎的研究大脑功能的技术。NIRS 相对于功能性磁共振成像（fMRI）， 氧合血红蛋白和脱氧血红蛋白的浓度变化，更精细的时间分辨率， 管理，以及缺点，最突出的是较差的空间分辨率，不能直接测量信号 从脑深部结构，并降低信噪比（SNR）。在这项研究中，我们比较了近红外光谱和功能磁共振成像信号， 来评估空间和时间上的相似性 方法：13名健康成人（平均年龄27.9岁，年龄范围21-42岁，6名男性）同时进行NIRS和fMRI 在完成四种实验范式：左手手指敲击（tap）、走/不走（nog）、判断路线的同时进行扫描 定向（jlo）和使用视觉空间刺激（维斯）的N-back工作记忆任务。我们进行了详细的比较 在时间和空间域中的信号。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/ （卢卡斯年度报告和 ISMRM 2011摘要）

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. INTRODUCTION: Near-infrared spectroscopy (NIRS) is an increasingly popular technology for studying brain function. NIRS offers several advantages relative to functional magnetic resonance imaging (fMRI), including the ability to measure concentration changes of both oxygenated and deoxygenated hemoglobin, finer temporal resolution, and ease of administration, as well as disadvantages, most prominently inferior spatial resolution, inability to directly measure signals from deep-brain structures, and decreased signal-to-noise ratio (SNR). In this study, we compared NIRS and fMRI signals to assess spatial and temporal similarities. METHODS: Thirteen healthy adults (mean age 27.9, age range 21-42, 6 males) underwent simultaneous NIRS and fMRI scanning while they completed four experimental paradigms: left finger tapping (tap), go/no-go (nog), judgment of line orientation (jlo), and an N-back working memory task using visuospatial stimuli (vis). We performed detailed comparisons of the signals in both temporal and spatial domains. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)