MRI ASSESSMENT OF PALLIDOTOMY LESION PLACEMENT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 MRI对帕金森病手术部位及术后定位的评估 近年来，射频苍白球腹后叶切开术(VPP)作为对症治疗帕金森S病(PD)难治性运动症状的方法已被广泛接受。一些中心已经报告了在控制特发性帕金森病患者的禁用运动障碍、开/关波动和其他运动症状方面的显著改善(Baron等人，1996；Dogali等人，1995；Iacono等人，1995；Johansson等人，1997；Lang等人，1997；Laitinen等人，1992a；Laitinen等人，1992b；Lozano等人，1995；Uitti等人，1997)。虽然人们普遍认为VPP对许多患者有帮助，但患者和手术中心的结果差别很大。这种差异的一个原因可能是由于病变位置和大小的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MRI Assessment of Pallidotomy Lesion Placement and Post-operative Localization in Parkinson's Disease In recent years, the use of radiofrequency ventroposterior pallidotomy (VPP) as a symptomatic treatment for the medically refractory motor symptoms of Parkinson¿s disease (PD) has been gaining widespread acceptance. A number of centers have reported significant improvements in controlling disabling dyskinesias, on/off fluctuations and other motor symptoms in patients with idiopathic PD (Baron et al., 1996; Dogali et al., 1995; Iacono et al., 1995; Johansson et al., 1997; Lang et al., 1997; Laitinen et al., 1992a; Laitinen et al., 1992b; Lozano et al., 1995; Uitti et al., 1997). Although there is a general agreement that VPP is helpful for many patients, results vary considerably between patients and centers performing the operation. One reason for this variability is likely due to differences in lesion placement and size.