TRANSPORT ACROSS THE SALMONELLA ENTERICA PDU MICROCOMPARTMENT SHELL

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 细菌微室是一组功能多样的蛋白质细胞器，它们将细胞中的特定反应途径限制在一个基于蛋白质的薄壳中。丙二醇利用(PDU)微室包含在某些肠道细菌中代谢1，2-丙二醇的反应， 包括沙门氏菌。PDU外壳由几种不同类型的几千个蛋白质亚基组装而成。在这里，我们报告了两个关键的壳蛋白，PduA和Pdut的晶体结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial microcompartments are a functionally diverse group of proteinaceous organelles that confine specific reaction pathways in the cell within a thin protein-based shell. The propanediol utilizing (Pdu) microcompartment contains the reactions for metabolizing 1,2-propanediol in certain enteric bacteria, including Salmonella. The Pdu shell is assembled from a few thousand protein subunits of several different types. Here we report the crystal structures of two key shell proteins, PduA and PduT.