Toxic Metals in the Northeast: From Biological To Environmental Implications

这个关于有毒金属的超级基金基础研究计划项目的总体目标是了解从环境和人为来源接触砷和汞对人类健康的影响。该计划包括三个生物医学和两个非生物医学研究项目，两个科学支持核心，以及一个行政，研究翻译和培训核心。项目2 （Hamilton）和8 （Stanton）是分子毒理学项目，研究砷引起其不良健康影响的分子机制，重点分别是内分泌干扰和膜蛋白运输和功能的破坏。项目7（陈）是一个生态毒理学项目，研究汞在鱼类体内的生物积累；项目9是一个植物生物学项目，研究砷在水稻体内的生物积累，每个项目都关注这些因素如何导致人类受到关注。项目4（卡拉加斯）正在检查接触砷和汞对人类健康的影响，重点关注新罕布什尔州孕妇后代的生殖和发育影响，这些孕妇通过食物（砷和汞）和井水（砷）接触到这些有毒物质。核心B（杰克逊）是微量元素分析核心，提供最先进的超低水平检测，定量和砷和汞的形态。Core E （Moore）是一个综合生物学核心，它为项目特定的分子生物学、基因组学、蛋白质组学、生物信息学、生物统计学和建模分析（每个都由达特茅斯的单个核心提供）提供全面的支持和整合知识，以便更充分地理解、整合并将这些知识转化为利益相关者。研究者的研究翻译核心旨在通过帮助他们以最有效和适当的方式向每个利益相关者群体传达适当的信息，从而有效地促进这种翻译。培训核心旨在利用其高度跨学科和协作的计划，以促进最有效的培训学生。目标是提供最好的科学，可用于更有效的基于科学的风险评估，用于预测砷和汞暴露的特定病理生理后果，用于评估基因-环境，剂-剂和其他复杂的环境相互作用，用于评估高危特别敏感的亚人群，并为这些暴露人群制定有效的干预措施。

The overall objective of this Superfund Basic Research Program Project on toxic metals is to understand the human health impact of exposure to arsenic and mercury from environmental and anthropogenic sources. This program consists of three biomedical and two non-biomedical research projects, two scientific support cores, and an Administrative, Research Translation and Training Core. Projects 2 (Hamilton) and 8 (Stanton) are molecular toxicology projects investigating the molecular mechanisms by which arsenic elicits its adverse health effects, focusing on endocrine disruption and disruption of membrane protein trafficking and function, respectively. Project 7 (Chen) is an ecotoxicology project examining how mercury bioaccumulates in fish, and Project 9 is a plant biology project focusing on bioaccumulation of arsenic in rice, each focusing on how these lead to human exposures of concern. Project 4 (Karagas) is examining the human health effects of exposure to arsenic and mercury, focusing on reproductive and developmental effects in offspring of pregnant women in New Hampshire who are exposed to these toxicants via their food (arsenic and mercury) and well water (arsenic). Core B (Jackson) is a Trace Elements Analysis Core that provides state-of-the-art ultra-low level detection, quantitation and speciation of arsenic and mercury. Core E (Moore) is an Integrative Biology Core that provides comprehensive support and integration of knowledge from the project-specific molecular biology, genomics, proteomics, bioinformatics, biostatistics and modeling analysis (each provided by individual cores at Dartmouth) to the program in order to more fully understand, integrate and translate this knowledge to stakeholders. The investigators' Research Translation Core is designed to effectively facilitate this translation by assisting them in communicating the proper information in the most effective and appropriate way to each stakeholder group. The Training Core is designed to exploit their highly interdisciplinary and collaborative program in order to foster the most effective training of their students. The goal is to provide the very best science that can be used for more effective science-based risk assessments, for predicting the specific patho-physiological consequences of arsenic and mercury exposure, for assessing gene-environment, agent-agent and other complex environmental interactions, for assessing specifically sensitive sub-populations at elevated risk, and for developing effective interventions for these exposed populations.