WORKSHOP ON ESR MICROSCOPY AND ITS APPLICATIONS IN BIOMEDICAL ESR IMAGING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在ESR社区的鼓励下，我们于今年1月在伊萨卡的康奈尔主校区举办了2011年ACERT研讨会，主题为“ESR显微镜及其在生物医学ESR成像中的应用”。研讨会的目的是提高生物医学界对电子自旋共振显微镜，特别是与电子自旋共振成像有关的潜力的认识。主题包括横截面最新的电子自旋共振显微镜和电子自旋共振成像技术。研讨会包括讲座、演示和最新ESR显微镜方法的“实践”体验，并充分讨论了将ESRM的新发展与当前生物医学ESR成像活动相结合的建议和计划。有来自Acert以外的参与者，Acert的工作人员参加，以及8位外部嘉宾演讲者，总共30名参与者。 应邀演讲的演讲者包括：Aharon Blank，“ESR显微镜--当前的能力和未来的方向”，Oleg Grinberg，“攀登到生物医学：历史综述”，Howard J.Halpern，“了解EPR氧气图像中三苯基的微观分布的重要性”，Periannan Kuppusamy，“用于氧传感的聚合物材料中的分子和晶体自旋探针”，John Marohn，“从氮氧化物自旋标记的力梯度检测电子自旋共振：通向单一氮氧化物敏感性的途径和在生物学中的应用”，Chang Seok Shon，“脉冲ESR显微镜的亚微米分辨率及其在生物/生物医学研究中的应用”，Sankaran Subramanian介绍了“时间域EPR成像的进展：迈向切片选择的、全球相位编码的基于回声的FT-EPR成像和体内定量血氧测定法”，Jay L.Zweier介绍了“新的Trityl探针及其在细胞氧合和氧化还原状态测量和成像中的应用”。Acert由两位演讲者代表发言，Jack H.Freed概述了Acert的“ESR显微镜”，Curt Dunnam谈到了我们正在Acert开发的“ESR显微镜仪器”。所有与会者都认为讲习班是成功的。开发ESR显微镜的研究人员和从事宏观医学ESR成像的研究人员之间进行了良好的思想交流。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. On the basis of encouragement from the ESR community, we presented the 2011 ACERT Workshop on "ESR Microscopy and Its Applications in Biomedical ESR Imaging" this January at the Cornell Main campus in Ithaca . The objective of the workshop was to raise awareness in the biomedical community to the potential of ESR Microscopy, especially in relation to ESR Imaging. Topics included a cross-section of up-to-date ESR Microscopy and ESR Imaging techniques. The workshop included lectures, demonstrations, and "hands-on" experience with the latest ESR Microscopy methods with ample discussions of proposals and plans to integrate the new developments in ESRM with current activities in biomedical ESR Imaging. There were participants from outside of ACERT, ACERT staff members who attended, and 8 outside guest speakers for a total of 30 participants. The invited speakers were: Aharon Blank on "ESR Microscopy - Current Capabilities and Future Directions", Oleg Grinberg on "Climbing to Bio-Med: An Historical Overview", Howard J. Halpern on "The Importance of Understanding the Microscopic Distribution of Trityl Radicals for EPR Oxygen Images", Periannan Kuppusamy on "Molecular and Crystalline Spin Probes Encapsulated in Polymeric Materials for Oxygen Sensing", John Marohn on "Force-Gradient Detection Of Electron Spin Resonance from a Nitroxide Spin Label: A Path to Single-Nitroxide Sensitivity and Applications in Biology", Chang Seok Shin on "Sub-micron Resolution of Pulsed ESR Microscopy and Its Application for Biological/Biomedical Research", Sankaran Subramanian on "Advances in time-domain EPR imaging: Towards slice-selected, globally phase-encoded Echo-based FT-EPR imaging and quantitative in vivo oximetry", and Jay L. Zweier on "New Trityl Probes and their use for Measurement and Imaging of Cellular Oxygenation and Redox State". ACERT was represented by two speakers, Jack H. Freed overviewed "ESR Microscopy at ACERT", and Curt Dunnam talked about "Instrumentation for ESR Microscopy" we are developing at ACERT. The Workshop was considered a success by all participants. Good exchange of ideas occurred between the researchers developing ESR microscopy and those involved in macroscopic medical ESR imaging.