Core C: Genomics and Analytical Chemistry

核心C：基因组学和分析化学。核心C包括克莉丝汀博士的综合专业知识 Skibola和Evan威廉姆斯，核心的两位联合领导人，在应用 尖端技术，以支持项目1-6的伯克利超级基金研究计划（SRP）。的 战略研究计划的总体目标是利用“组学”技术和现代分析方法， 用于人类研究和场地修复的标记物，以便更好地检测和修复 为重点化学品和环境中新出现的污染物提供超级基金;并更好地评估风险 它们对人类健康的影响。核心C是专门为提供实验室而设立的 项目1-6的基础设施和专业知识，以实现这些目标。为了实现项目的许多目标1- 为了确保他们的成功，调查人员需要获得机会、专门知识和技术支持， 功能基因组学、转录组学、蛋白质组学、遗传学和表观遗传学等技术。 项目3是一项流行病学研究，需要对生物样本进行有效的处理和管理 这样这些技术才能被应用。为了实现这些目标，详细收集和存储 已经设计了一些方案，核心将为遗传和蛋白质组研究提供设施， 将在项目1-4中进行。项目3和项目5也需要精密的质谱分析 将由QB 3/化学质谱机构提供的分析。核心还将提供 支持通过伯克利筛选项目6对有毒代谢物进行高通量分析 中心核心C的具体目标是：1）处理、维护和储存生物样品和细胞系; 2)为基因表达和表观遗传学研究提供设施和方法; 3）提供分析 支持蛋白质组学研究，通过以下方法鉴定蛋白质、有机和无机化合物： 我们的QBS/化学质谱设施和毒性筛选支持; 4）提供设施和 分析遗传多态性的方法;以及，5）在我们的QB 3 DNA上提供测序能力 排序设施。核心小组将在所有必要领域提供专门知识和分析支助，沿着 核心D的计算生物学技能，将允许成功完成项目1-6的 伯克利SRP。

Core C: Genomics and Analytical Chemistry. Core C comprises the combined expertise of Drs. Christine Skibola and Evan Williams, the two co-leaders ofthe Core, who have broad experience in the application of cutting-edge technologies to support Projects 1-6 ofthe Berkeley Superfund Research Program (SRP). The overall goals of the SRP are to use 'omic' technologies and modern analytical methods to develop biological markers for application in human studies and site remediation to allow better detection and remediation of Superfund priority chemicals and emerging contaminants in the environment; and to better evaluate the risk they pose to human health. Core C is set up specifically for the purposes of providing the laboratory infrastructure and expertise for Projects 1-6 to achieve these goals. To meet many of the Aims of Projects 1- 4 and ensure their success, investigators require access, know-how and technical support to apply cuttingedge technologies such as functional genomics, transcriptomics, proteomics, genetics and epigenetics. Project 3 is an epidemiological study that requires effective handling and management of biological samples so that these technologies can be applied. To accomplish these goals, detailed collection and storage protocols have been designed and the Core will provicie facilities for the genetic and proteomic studies that will be conducted in Projects 1-4. Projects 3 and 5 will also require sophisticated mass spectrometry analyses that will be provided by the QB3/Chemistry Mass Spectrometry Facility. The Core will also provide support for high-throughput analysis of toxic metabolites for Project 6 through the Berkeley Screening Center. The specific aims of Core C are to: 1) process, maintain and store biological samples and cell lines; 2) provide facilities and methodologies for gene expression and epigenetic studies; 3) provide analytical support for proteomic studies, for the identification of proteins and organic and inorganic compounds through our QBS/Chemistry Mass Spectrometry Facility, and toxicity screening support; 4) provide facilities and methodologies to analyze genetic polymorphisms; and, 5) provide sequencing capabilities at our QB3 DNA sequencing facility. The Core will provide expertise and analytical support in all required areas that, along with the computational biology skills of Core D, will allow for the successful completion of Projects 1-6 of the Berkeley SRP.