APOPTOSIS AND CELL DEATH RESEARCH

细胞凋亡和细胞死亡研究计划的成员将他们的注意力集中在基本的 凋亡细胞死亡的分子机制和翻译研究，在一个模型下运作， 现代生物医学研究的主要技术（细胞和分子生物学，生物化学，化学， 结构生物学）包含在该计划中。构成细胞核心的所有蛋白质家族 死亡信号被深入报道，并构成现有的四个主题的计划，从死亡 受体和死亡启动信号复合物（主题1），半胱天冬酶（主题2）， 凋亡蛋白（IAP;主题3）和Bcl-2家族成员，包括细胞死亡的整合 线粒体的信号传导（主题4）。越来越多的重点也被放在非凋亡形式的细胞 死亡是一个发展的主题。在过去的资助期间，我们也见证了一个强劲的新系列的增长 利用计划成员的综合才能， 靶向抗凋亡蛋白的分子癌症治疗剂。该方案的总体目标是 提供一个共享试剂、技术和想法的环境，以促进发现 这是调节死亡细胞命运决定的基本机制的过程。 该计划自上次更新以来，通过招聘两名新的全职教师和一名 兼职成员的专业知识，补充了原来的教师的利益，并已 在快节奏的细胞凋亡和细胞死亡研究领域保持领先地位。盖伊医生 Salvesen继续担任项目负责人。该计划是高度协作和互动的联合 实验室会议，研究生和博士后研究员的联合指导，每月培训 演讲，每月教师会议，并参与和领导几个计划项目赠款 和其他合作筹资机制。结果。计划资金雄厚，目前的年度总额 赠款资金为2290万美元（直接1340万美元）。项目成员领导或参与5个POI（4个来自NCI）， 和10个U 54/U19/U 01赠款（3个来自NCI）以及其他几个联邦和州合作赠款， 证明该计划中的高水平合作活动。程序的生产力进一步反映在 自上次审查以来发表了523篇文章，2008年发表了96篇项目文章，占项目内研究的17%。 13%的项目间合作。

Members of the Apoptosis & Cell Death Research Program direct their attention towards fundamental molecular mechanisms of apoptotic cell death and translational research, operating under a model where the major technologies of modern biomedical research (cell and molecular biology, biochemistry, chemistry, and structural biology) are encompassed within the Program. All protein families that constitute the core of cell death signaling are covered in depth and constitute the existing four themes of the program, from the death receptors and death initiating signaling complexes (theme 1), to the caspases (theme 2), the Inhibitors of Apoptosis Proteins (lAPs; theme 3), and the Bcl-2 family members, including the integration of cell death signaling by mitochondria (theme 4). Increasing emphasis is also being placed on non-apoptotic forms of cell death as a developing theme. This past funding period has also witnessed the growth of a robust new series of collaborations within the Program that use the combined talents of the program members to identify small molecule cancer therapeutics targeting anti-apoptotic proteins. The overarching objective of the program is to provide an environment where reagents, techniques and ideas are shared to enhance the discovery process of the basic mechanisms that regulate the death cell fate decision. The Program has grown since the last renewal by the recruitment of two new full faculty members and one adjunct member with expertise that complements the interests of the original faculty members, and has maintained a leadership position in the fast-paced field of apoptosis and cell death research. Dr. Guy Salvesen continues as the Program Leader. The Program is highly collaborative and interactive with joint laboratory meetings, joint mentoring of graduate students and postdoctoral fellows, monthly trainee presentations, monthly faculty meetings, and participation and leadership in several Program Project grants and other collaborative funding mechanisms. As a result. Program funding is strong with current total annual grant funding of $22.9MM ($13.4MM direct). Program members lead or participate in 5 POIs (4 from NCI), and 10 U54/U19/U01 grants (3 from NCI) and several other federal and state collaborative grants, further attesting to high-level of collaborative activity in the program. Program's productivity is further reflected by 523 publications since last review, and by 96 Program publications in 2008, which represent 17% of intraand 13% of inter-programmatic collaborations, respectively.