Core B - MYELOMA TISSUE CORE

专注于多发性骨髓瘤的基础、翻译和临床科学家必须能够从分子水平上 特征化的细胞系模型系统，尤其是临床注释的新鲜和冷冻的初级组织 样本，以检验和验证他们的假设。骨髓瘤组织核心的主要目标是 与每个孢子项目、核心和计划一起确保高效地采购、存储和分发 安德森癌症中心的实验室和临床组织样本。经过验证的标准化 已经为所有活动建立了操作程序，并在 调查员、研究护士、生物统计学家。血液病理学家将提供最佳的组织 每个样品的采集、标准化处理、准确分析和安全存储。这些样品 将与相关的患者临床和实验室数据相关联，并根据 具有所有适用的监管指南。该组织核心还将被用于新的和强大的生物标志物 翻译假说的开发和准确测试。这个核心有四个具体目标： 具体目标1.建立和维护完整的细胞、血清、DNA、RNA和蛋白质的储存库 取自血浆细胞患者的血液、骨髓和其他组织样本 安德森癌症中心的癌症患者。样本的收集和处理是在 诊断、治疗期间、缓解或复发。这个核心将把组织标本分发给孢子 调查人员进行分析，同时提供全面的血液病理特征和详细的 收集和保存参数的注释。组织核心还维护着一系列 骨髓瘤细胞系，并将作为存储和分发新的 发达的细胞系。 具体目标2.维护一个全面的、预期的、互动的数据库，包括详细的临床 以及浆细胞营养不良患者的病理资料。 具体目标3.促进孢子间和孢子内的合作以及与非孢子的合作 研究人员通过获取和分发往返于孢子的临床样本资源 调查人员和安德森癌症中心内的其他人，以及其他国家或 国际消息来源。这包括开发信息系统并与其他孢子站点共享。 具体目标4.为孢子研究人员提供现货和定制的反相蛋白质阵列。

Basic, translational, and clinical scientists focusing on multiple myeloma must have access to molecularly characterized cell line model systems, and especially to clinically-annotated fresh and frozen primary tissue samples, to test and validate their hypotheses. The main objective ofthe Myeloma Tissue Core is to work with each SPORE Project, Core, and Program to insure efficient procurement, storage, and distribution of laboratory and clinical tissue samples at the M. D. Anderson Cancer Center. Validated standardized operating procedures have been established for all activities, and continuous communication between the investigators, research nurses, biostatisticians. and hematopathologists will provide for optimal tissue collection, standardized processing, accurate analysis, and safe storage of each sample. These samples will be associated with relevant patient clinical and laboratory data obtained and maintained in accordance with all applicable regulatory guidelines. This Tissue Core will also be used for novel and robust biomarker development and accurate testing of translational hypotheses. There are four specific aims for this Core: Specific Aim 1. To develop and maintain a repository of intact cells, serum, DNA, RNA, and protein derived from blood, bone marrow, and other tissue specimens obtained from patients with plasma cell dyscrasias at the M. D. Anderson Cancer Center. Samples are collected and processed at the time of diagnosis, during therapy, in remission, or at relapse. This Core will distribute tissue specimens to SPORE investigators for analysis, while providing comprehensive hematopathologic characterization with detailed annotation of parameters of collection and preservation. The Tissue Core also maintains a collection of myeloma cell lines, and will act as a centralized repository for the storage and distribution of newly developed cell lines. Specific Aim 2. To maintain a comprehensive, prospective, interactive database with detailed clinical and pathologic data for patients with plasma cell dyscrasias. Specific Aim 3. To facilitate inter- and intra-SPORE collaborations, and collaborations with non-SPORE investigators, through acquisition and distribution of clinical sample resources to and from SPORE investigators and others within the M. D. Anderson Cancer Center, as well as with other national or international sources. This includes developing and sharing the informatics systems with other SPORE sites. Specific Aim 4. To provide stock and customized reverse phase protein arrays to SPORE investigators.