2012 Chemotactic Cytokines Gordon Research Conference & Gordon Research Seminar

描述(申请人提供)：趋化因子，结构上同源的，功能上不同的趋化细胞因子，以及它们同源的经典和非典型受体组成了一个复杂的分子网络，几乎涉及人类健康和疾病的所有方面。2012年戈登趋化细胞因子研究会议(GRC)是一次完全致力于了解这些重要分子的世界首要会议。这将是我们的第10届趋化因子GRC，自1994年以来每隔一年举行一次，当时趋化因子作为人类基因组中最大的细胞因子基因家族首次亮相。与本系列之前的每一次会议类似，2012年趋化因子GRC将汇集来自广泛生物医学学科的科学家，展示涵盖趋化因子功能方方面面的最新未发表研究成果，并提供一个高质量的科学论坛，讨论它们的潜在影响，包括翻译到临床。本次会议的计划将涉及趋化因子的基本生化和生物学方面，涉及它们对白细胞迁移、迁徙、免疫组织组织和功能的贡献；趋化因子在炎症中的作用，包括不同器官和组织中的感染性疾病和自身免疫；以及趋化因子在癌症发病机制中的多方面贡献。此外，在本次会议的历史上，我们将首次介绍何戈登研究研讨会(GRS)，这是一个面向研究生和博士后水平的板凳科学家的卫星会议。GRS将提供一个论坛，年轻的研究人员可以在这里展示他们的工作，并从他们的同行和一个选定的高级专家小组那里获得对他们正在进行的研究项目的反馈。GRS将在趋化因子研究领域内促进基层整合和联网。我们完全期待这次会议的科学讨论、研究演讲、海报会议和与会者之间的非正式互动将有助于增进我们对趋化因子参与疾病发病机制的分子机制的理解。这将为开发新的合作项目奠定基础，导致新的发现，并最终产生治疗包括炎症和自身免疫性疾病以及癌症在内的人类衰弱疾病的新疗法和方法。 与公共卫生相关：戈登趋化细胞因子研究会议和戈登研究研讨会将汇聚来自生物医学各个层面的趋化因子科学家，包括知名研究人员、初级研究人员和未来几代趋化因子研究人员。本次会议期间的科学陈述、讨论和海报会议将扩大我们对趋化因子促进健康和疾病的机制的理解。预计这些会议传统上具有的合作和合作氛围将为智力开发、交流和未来的合作提供完美的环境，这些对保持该领域在科学创新和发现方面的前沿是至关重要的。

DESCRIPTION (provided by applicant): Chemokines, the structurally homologous, functionally distinct chemotactic cytokines together with their cognate classical and atypical receptors comprise a complex molecular network involved in nearly all aspects of human health and disease. The Gordon Research Conference (GRC) on Chemotactic Cytokines 2012 is a world premier meeting devoted entirely to understanding these important molecules. This will be our 10th Chemokine GRC, which has been held every other year since 1994, when chemokines first burst onto the scene as the largest cytokine gene family in the human genome. Similar to each preceding conference in this series, Chemokine GRC 2012 will bring together scientists from a broad range of biomedical disciplines to showcase the latest unpublished research findings that cover all aspects of chemokine function and provide a high-quality scientific forum to discuss their potential implications, including translation to the clinic. The program of this meeting will cover basic biochemical and biological aspects of chemokines as related to their contributions to leukocyte migration, emigration, immune tissue organization and function; the role of chemokines during inflammation, including infectious diseases and autoimmunity in distinct organs and tissues; and multifaceted contributions of chemokines to cancer pathogenesis. In addition, for the first time in the history of this conference, we will introduce he Gordon Research Seminars (GRS), a satellite meeting for bench scientists at the graduate and postdoctoral level. GRS will provide a forum where young researchers can present their work and receive feedback on their ongoing research projects from their peers and a selected panel of senior experts. GRS will promote grassroots level integration and networking within the field of chemokine research. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in disease pathogenesis. This will set the basis for the development of new collaborative projects leading to new discoveries and ultimately resulting in new therapies and approaches to treat debilitating human disease, including inflammatory and autoimmune diseases and cancer. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Chemotactic Cytokines and the Gordon Research Seminar will bring together chemokine scientists from a variety of biomedical disciplines at all levels of this endeavor, including established investigators, junior investigators, and future generations of chemokine researchers. Scientific presentations, discussions and poster sessions during this conference will expand our understanding of the mechanisms by which chemokines contribute to health and disease. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized these conferences will provide the perfect setting for the intellectual development, cross-fertilization and future collaborations that are so vital to keep this field at the forefront of scientific innovation and discovery.