BIOSTATISTICS CORE

生物统计学核心的作用是支持前列腺癌孢子研究人员在他们的 研究工作，包括实验室实验和临床试验的设计和分析。在临床前阶段 研究，核心成员将协助制定试验设计和分析 在研究结束时对数据进行解释。在临床试验设计阶段，核心成员将 与首席调查员一起进行方案审查。在此审查的基础上，为 将提供方案，概述主要的科学目标、要研究的人口、初级和 次要终点、实验设计、必要时的随机化程序、分析计划和 目标样本量以概率术语证明是合理的。在试验结束时，将进行数据分析 执行以评估议定书中规定的主要和次要终点的结果。 生物统计核心的具体目标是： 目标1：帮助设计和分析以实验室为基础的前列腺癌研究 目标2：有助于前列腺癌临床研究的设计和分析 目标3：开发有助于推进前列腺癌研究的统计方法

The role of the Biostatistics Core is to support the investigators of the SPORE in Prostate Cancer in their research efforts, including laboratory experiments and the design and analysis of clinical trials. In preclinical studies, core members will assist in the formulation of the experimental design and in the analysis and interpretation of the data at the conclusion of the study. In the clinical trial design phase, a core member will conduct a protocol review with the principal investigator. Based on this review, a statistical section for the protocol will be provided, outlining major scientific objectives, population to be studied, primary and secondary endpoints, experimental design, a randomization procedure if necessary, analysis plans, and a targeted sample size justified in probabilistic terms. At the conclusion of the trial, data analyses will be performed to assess outcomes of the primary and secondary endpoints stated in the protocol. The specific aims of the Biostatistics Core are to: Aim 1: Contribute to the design and analysis of laboratory-based prostate cancer research Aim 2: Contribute to the design and analysis of clinical studies in prostate cancer Aim 3: Develop statistical methodology that will assist in the advancement of prostate cancer research