MRI-Guided Cardiac Focused Ultrasound Ablation

该项目的长期目标是开发一种非侵入性的肥厚性梗阻治疗方法。 心肌病(HOCM)。聚焦超声(Fus)是一种很有前途的无创热疗技术。 消融。这里提出的努力解决了使用聚焦超声的主要技术挑战 心脏治疗。具体地说，我们的目标是1)评估磁共振(MR)引导下的疗效 相控阵聚焦超声(FUS)治疗非侵入性消融心肌，包括 在胸腔和肺存在束路阻塞的情况下靶向心脏的策略和 使消融与心脏节律同步，2)开发强大的实时目标和温度 使用磁共振成像对心脏进行监测，以及3)执行初始测试和评估 系统。 我的直接职业目标是开发必要的融合消融和磁共振成像策略，以使核磁共振制导 FUS消融术是治疗HOCM的一种非侵入性选择。在指导阶段，我 参与了放射科、心内科和 斯坦福大学电气工程专业。我能够对心脏生理学有所了解， 除了进一步发展我在心脏磁学方面的专业知识外，我还学习了治疗性超声波的原理 磁共振成像和磁共振测温。我已经接受了加州大学旧金山分校的教职 弗朗西斯科在放射和生物医学成像系，在那里我可以独立研究和 开发具有潜在临床应用价值的MR引导聚焦超声技术。我长期的职业生涯 目标是继续为磁共振引导的聚焦超声治疗领域做出贡献，并使 通过探索新的、侵入性较小的治疗方案，对患者护理产生根本性影响。

The long-term goal of this project is to develop a noninvasive treatment for hypertrophic obstructive cardiomyopathy (HOCM). Focused ultrasound (FUS) is a promising technique for noninvasive thermal ablation. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the heart. Specifically, we aim to 1) evaluate the efficacy of magnetic resonance (MR) guided phased array focused ultrasound (FUS) therapy to non-invasively ablate the myocardium, including strategies to target the heart in the presence of beam path obstruction by ribcage and lungs and to synchronize the ablation to the rhythm of the heart, 2) develop robust real-time targeting and temperature monitoring in the heart using magnetic resonance imaging, and 3) perform initial testing and evaluation ofthe system. My immediate career goal is to develop the necessary FUS ablation and MR imaging strategies to make MRguided FUS ablation a noninvasive alternative for the treatment of HOCM. During the mentored phase, I have participated in interdisciplinary collaboration between the Departments of Radiology, Cardiology, and Electrical Engineering at Stanford University. I was able to gain an understanding of cardiac physiology and ofthe principles of therapeutic ultrasound, in addition to further developing my expertise in cardiac magnetic resonance imaging and MR-thermometry. I have accepted a faculty position at University of California San Francisco in the Department of Radiology and Biomedical Imaging where I can independently research and develop MR-guided focused ultrasound techniques with potential clinical applications. My long-term career goal is to continually contribute to the field of MR-guided focused ultrasound therapy and to make a fundamental impact on patient care_by exploring new, less invasive treatment options.