Training in Developmental Hematology

描述（由申请人提供）：儿科血液疾病研究为理解调节造血的基本机制提供了重要范例。与成人血液系统疾病不同，许多儿科疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。对许多儿童血液病的分子发病机制知之甚少。在加州大学洛杉矶分校，我们拥有大量的跨学科研究人员，他们的研究重点是与发育血液学相关的广泛主题。因此，我们提出了一个独特的培训计划，专门侧重于儿科血液疾病，通过整合各种学科，包括分子和细胞造血，替代生物体模型，干细胞移植，止血和血栓形成，输血医学，蛋白质组学/基因组学，血液恶性肿瘤，治疗学和数学建模的新技术。鉴于儿科血液学的医生-科学家数量不断下降，发育血液学的培训计划对推进该领域至关重要。在这个应用程序中，我们寻求资助4博士后研究员每年5年。研究员将是医学博士，医学博士/博士，或博士。学员将有机会在22个教师实验室之一开展研究。学员将根据他们的学术潜力和研究成果从大约20至30名博士后研究员中挑选。任命为期两年，第二年的任命取决于进度报告。学员将被要求参加多学科期刊俱乐部，凝血课程和研讨会。他们还将通过病理学系参加发育血液学的必修课程。儿科血液学/肿瘤学学员将有望满足他们的奖学金监督委员会每6个月，以监测进展和生产力。他们将在国家会议上介绍他们的工作。许多研究者都有预先存在的合作和出版物。我们希望利用UCLA的优势，包括跨学科研究人员的广度和深度，培养儿科血液学领域未来的研究人员和领导者。

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of many of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies in proteomics/genomics, hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology is critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a pool of approximately 20 to 30 postdoctoral fellows based on their academic potential and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will be required to participate in multidisciplinary journal clubs, a course on coagulation, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. Pediatric Hematology/Oncology trainees will be expected to meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre- existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology.