Training Grant: Functional Proteomics of Aging

描述(由申请人提供)：我们寻求支持明尼苏达大学为博士后和博士后学员提供的衰老功能蛋白质组学跨学科培训计划。该培训计划包括两个主要部分：(1)研究培训，重点是使用蛋白质组技术来揭示与年龄相关的组织功能丧失背后的分子细节。(2)老年学和蛋白质组学的授课和体验式培训，为学员在老龄研究领域取得成功奠定坚实的基础。该培训计划的研究部分包括三个研究领域，重点是在衰老过程中保持生理功能：肌肉(Thomas、Thompson、Lowe、Arriaga、Erasti)、中枢神经系统(Olsen、Ferrington、Low、Erasti)以及新陈代谢和长寿(Bernlohr、Arriaga、Griffin、Hendrickson、Kim、Low)。这些项目的教职员工来自明尼苏达大学的两个研究生项目：生物化学、分子生物学和生物物理学(BMBB)和康复科学(RSC)。培训学院利用蛋白质组学分析来揭示老年组织中发生的蛋白质含量、结合伙伴和翻译后修饰的变化。这些信息有助于确定与年龄相关的蛋白质结构和功能变化的机制基础。我们的研究得到了优秀核心的支持，这些核心配备了各种最先进的质谱仪，如质谱学和蛋白质组学中心，以及培训学院实验室的其他分析设备。培训计划还将包括通过老年学和蛋白质组学课程进行的授课培训，以及通过研讨会、研讨会、期刊俱乐部和与计划教职员工举行的小组会议进行的老龄研究经验培训。完成培训计划的课程将使学员有资格攻读老年学研究生辅修课程，从而为学员未来的职业目标提供方向。体验式培训旨在最大限度地促进学员和来自多个实验室的培训人员之间的互动。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发所需的智力和技术工具，以在老龄化研究中作为独立调查人员和教育工作者从事富有成效的职业生涯。

DESCRIPTION (provided by applicant): We seek support for an interdisciplinary Training Program in Functional Proteomics of Aging for both predoctoral and postdoctoral trainees at the University of Minnesota. This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component of this Training Program consists of three research areas that focus on retaining physiological function during aging: muscle (Thomas, Thompson, Lowe, Arriaga, Ervasti), the central nervous system (Olsen, Ferrington, Low, Ervasti) and metabolism and longevity (Bernlohr, Arriaga, Griffin, Hendrickson, Kim, Low). These Program Faculty members are drawn from two graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB) and Rehabilitation Sciences (RSc). Proteomic analysis is utilized by Training Faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers, such as the Center for Mass Spectrometry and Proteomics, and other analytical equipment in Training Faculty laboratories. The Training Program will also include both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via seminars, symposia, journal clubs, and group meetings with Program Faculty members. Completion of the Training Program coursework will qualify trainees for a Gerontology Graduate Minor, thus providing direction for trainees' future career goals. The experiential training is designed to maximize interaction among trainees and Training Faculty from multiple labs. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.