Neurobehavioral Bases of Emotion Regulation and Dysregulation in Adolescence

本中心为威斯康星大学麦迪逊分校的一项高度跨学科研究项目寻求支持，该项目使用情感神经科学的观点来进一步了解焦虑和情绪障碍（内化障碍）风险的潜在神经和行为基础，并特别关注青少年时期。青春期是患这些疾病的风险显著增加的时期，也是大脑功能和结构发生成熟和经验引起的巨大变化的时期。此外，流行病学证据表明，如果一个人在青少年时期被诊断出患有这些疾病，其成年后患这些疾病的风险将增加2-3倍。通过对非人类灵长类动物和人类的高度整合和合作研究项目，该中心将在未来五年内产生新的数据，涉及大脑机制、行为、内分泌和情绪调节和情绪反应中个体差异的自主相关。该项目涉及威斯康星大学麦迪逊分校的五位PI。一个主要的焦点将放在青少年大脑回路的早期生活预测因素上，这些回路是情绪调节的基础，也是易受内化障碍影响的个体中这些回路的异常。研究策略也将允许检查早期素质和青春期后期脆弱性之间的关系，因为纵向数据在两个人类群体中都是可用的。在非人类队列中，将执行早期应激的明确操作。该中心还将提供新的策略，利用大脑功能和结构分析焦虑和情绪障碍的异质性。参与本中心的每个pi都有悠久的合作历史。pi之间有许多双向、三向和四向合作。所有人都与至少一个其他PI一起发表过文章，许多人与许多中心PI一起发表过文章。每个项目都涉及所有pi的协作参与。整个工作计划严重依赖于整个团队，工作范围和多层次分析只有在中心内才有可能。这个团队经验丰富，有着良好的合作记录，过去一直非常富有成效，并且有望对青少年内化障碍的神经和行为基础产生新的见解，这将直接为诊断和治疗提供信息。

This Center seeks support for a major program of highly interdisciplinary research at the University of Wisconsin-Madison that uses an affective neuroscience perspective to further our understanding of the underlying neural and behavioral bases of risk for anxiety and mood disorders (internalizing disorders), with a specific focus on the adolescent period. Adolescence is a period of extraordinarily increased risk for these disorders and it is also a period during which dramatic maturational and experience-induced alterations in brain function and structure take place. Moreover, epidemiological evidence indicates a 2-3 fold increased risk in adulthood for these disorders if an individual had a diagnosis as an adolescent. Through a highly integrated and collaborative program of research in non-human primates and humans that involves five PI's all on the faculty at UW-Madison, this Center will produce novel new data over the next five years on the brain mechanisms and behavioral, endocrine and autonomic correlates of individual differences in emotion regulation and emotional reactivity. A major focus will be on early life predictors of adolescent brain circuits that underlie the regulation of emotion and abnormalities in these circuits in individuals vulnerable to internalizing disorders. The research strategies will also permit the examination of relations between early diatheses and later vulnerability in adolescence since longitudinal data are available in both human cohorts. In the non-human cohort, an explicit manipulation of early stress will be performed. The Center will also provide new strategies for parsing the heterogeneity of anxiety and mood disorders using profiles of brain function and structure. Each of the PIs involved in this Center have a long history of collaboration. There are many two, three and four way collaborations among the PIs. All have published with at least one other PI and many have published with many of the Center PIs. Each of the projects involves the collaborative involvement of all of the PIs. This overall program of work is critically dependent upon this entire team and the scope of the work and the multiple levels of analysis would only be possible within a Center. This team is highly experienced, has a demonstrated record of working well together, has been extraordinarily productive in the past, and promises to produce novel insights about the neural and behavioral bases of adolescent internalizing disorders that will directly inform diagnosis and treatment.