Genetic and Pathophysiologic Investigation of Panic Disorder Typologies

描述（由申请人提供）：这个K 01指导研究科学家发展奖建议提供精神病和分子遗传学方面的高级研究培训，重点研究惊恐障碍（PD）。Kenneth S.博士肯德勒医学博士世界著名的精神病遗传学研究者，将担任Roxann Roberson-Nay博士的主要导师。培训将在弗吉尼亚联邦大学的弗吉尼亚精神病和行为遗传学研究所进行，该研究所为开展培训和研究提供了丰富、激励人心的环境。该申请概述了一个培训计划，将使罗伯逊-奈博士联合收割机结合她以前的临床经验，在焦虑症的研究和神经影像学与新获得的技能，在精神病和分子遗传学。拟议的培训目标将在五个领域提供进一步的指导和指导：a）流行病学/遗传流行病学，B.）关联方法，c.）分子遗传学，d.）呼吸生理学和神经生理学，以及e.）负责任地进行研究。该奖项的研究重点是PD，这是一种以意想不到的反复发作的恐慌为特征的衰弱性精神疾病。为了实现其研究目标，研究者将采用多方法研究PD类型学，其中她将检查PD的表型变异，以确定临床相关和有意义的亚型。这些结果将被用来指导多模式的方法来检查PD类型。也就是说，研究者将检查PD类型的风险因素和进展，并寻求确定机制（即，遗传的，环境的），赋予他们的脆弱性。最后，研究者试图描绘特定的神经回路有助于PD亚型和验证生物标志物。作为未来的步骤，研究者将应用从本文所述的培训和研究目的中学到的知识来检查与PD类型学相关的分子遗传学，并将获得的有关PD亚型的知识应用于治疗反应的检查，目的是提高治疗疗效。拟议的培训将为研究者提供作为独立临床研究者进行创新，高质量精神病遗传研究所需的独特技能基础和经验。

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Development Award proposes to provide advanced research training in psychiatric and molecular genetics with a research focus on panic disorder (PD). Dr. Kenneth S. Kendler, M.D., a world renowned researcher in psychiatric genetics, will serve as Dr. Roxann Roberson-Nay's primary mentor. The training will take place at the Virginia Institute for Psychiatric and Behavioral Genetics of Virginia Commonwealth University, which provides a rich, stimulating environment for the conduct of training and research. This application outlines a training program that will enable Dr. Roberson-Nay to combine her previous clinical experience in anxiety disorders research and neuroimaging with newly acquired skills in psychiatric and molecular genetics. The proposed training goals will provide further instruction and mentorship in five areas: a.) epidemiology/genetic epidemiology, b.) association methods, c.) molecular genetics, d.) respiratory physiology and neurophysiology, and e.) responsible conduct of research. The research focus of the award is on PD, a debilitating psychiatric disorder characterized by unexpected, recurrent panic attacks. For her research aims, the investigator will take a multimethod approach to the study of PD typologies wherein she will examine the phenotypic variance in PD for the purpose of identifying clinically relevant and meaningful subtypes. These results will be used to guide a multimodal approach to the examination of PD typologies. That is, the investigator will examine risk factors and progression of PD typologies as well as seek to identify mechanisms (i.e., genetic, environmental) that confer vulnerability to them. Finally, the investigator seeks to delineate specific neural circuits contributing to PD subtypes and validate biological markers. As a future step, the investigator will apply what is learned from the training and research aims described herein to examine the molecular genetics associated with PD typologies and apply acquired knowledge regarding PD subtypes to the examination of treatment response, with the goal of improving treatment efficacy. The proposed training will provide the investigator with a unique skill base and experience needed to conduct innovative, high quality psychiatric genetic research as an independent clinical investigator.