JEOL JEM-1400 Transmission Electron Microscope

描述(由申请人提供)：本建议书要求资金购买JEOL JEM-1400透射电子显微镜(TEM)，以取代我们位于亚利桑那州健康科学核心成像设施的老化的、已有21年历史的飞利浦CM12S。现有的CM12S的维修停机时间越来越长，更换部件变得越来越难获得(FEI将仅支持现有的CM-12 30-36个月-见附信)。JEOL JEM-1400将是亚利桑那大学基础和临床研究人员可用的主要透射电子显微镜。用新的透射电子显微镜取代老化的显微镜将确保在可预见的未来亚利桑那大学的研究人员可以使用这项技术。JEOL JEM-1400是一种基本的120千伏瞬变电磁，满足了我们研究人员的需求。它使用方便，具有多个数字成像选项，并且可以从远程位置进行操作。该仪器将支持NIH资助的8个主要用户，他们的研究需要瞬变电磁。使用JEOL JEM-1400收集的细胞和组织超微结构数据将用于增加我们对结肠癌和食道癌、心脏和肌肉功能和功能障碍、有毒物质在器官发育过程中的影响、心血管功能和免疫功能的了解。

DESCRIPTION (provided by applicant): Funds are requested in this proposal to purchase a JEOL JEM-1400 transmission electron microscope (TEM) to replace our aging, 21 year old Philips CM12S located in the Arizona Health Sciences Core Imaging Facility. The existing CM12S has increasing downtime for repairs with replacement parts becoming more difficult to obtain (FEI will only support the existing CM-12S for 30-36 months - see attached letter). The JEOL JEM-1400 will be the primary TEM available to basic and clinical researchers at the University of Arizona. Replacement of the aging microscope with a new TEM will insure that this technology is available to researchers at the University of Arizona for the foreseeable future. The JEOL JEM-1400 is a basic 120 kV TEM that meets the needs of our researchers. It is easy to use, has several digital imaging options and can be operated from remote locations. The instrument will support 8 NIH-funded major users who require the TEM for their research. Cellular and tissue ultra structural data collected using the JEOL JEM-1400 will be used to increase our understanding of colon and esophageal cancer, heart and muscle function and dysfunction, effects of toxicants during organ development, cardiovascular function, and immune function.