Cardiac MR and CT Research

描述（由申请人提供）：我们寻求NIH继续支持我们的心脏成像研究培训计划。基金要求每年支持8名研究员。我们的课程强调现代心脏磁共振（MR），正电子发射断层扫描（PET）和计算机断层扫描（CT）成像科学的基础（博士）和临床（MD）科学家的教育。我们的目标是培养未来心脏成像的领导者，强调新的发展和转化研究。该培训项目以MGH心脏MR-PET-CT项目为基础，是一个心脏病学和放射学的联合项目，这一模式极大地增加了合作的机会。课程包括教学讲座，包括哈佛公共卫生学院的临床有效性课程、实验室练习和个人研究项目。该项目的一个主要优势是我们优秀的教师，他们每个人都在心脏成像科学的前沿进行研究。该学院由21名医学博士和/或博士组成，他们在心脏病学、放射学、物理学、计算机科学和成果研究方面具有专业知识。他们总共有超过50个活跃的校外资助，并在基础和临床心脏成像研究的各个方面指导了250多名前/博士后研究员。在麻省总医院、哈佛医学院和麻省理工学院社区的教师、学员和有成就的研究人员之间进行广泛的合作，进一步增加了该计划的科学影响。广泛接触积极进取的科学家和忠诚的导师，强调个人的科学成就，为成功培训领导者在心脏病学中使用这些重要技术提供了条件。在NIH支持的最初四年中，所有NIH培训生职位都被填补，培训生撰写或合作撰写了50多篇同行评审的出版物。所有完成培训的学员都获得了学术医疗中心的工作岗位或继续参加学术培训项目。为了加强该计划，我们增加了技术人员和新型设备，为心脏成像科学发展领域的学员提供了额外的研究机会，包括斑块活动的FDG PET成像，使用光学和MR探针的分子成像，动物模型的9.4T成像，新型心脏图像重建方法以及使用双源心脏CT在化学应激下同时成像狭窄和功能。

DESCRIPTION (provided by applicant): We seek continued NIH support for our Training Program in cardiac imaging research. Funds are requested to support 8 fellows annually. Our program emphasizes the education of basic (PhD) and clinical (MD) scientists in modern cardiac magnetic resonance (MR), positron emission tomography (PET) and computed tomography (CT) imaging science. Our goal is to develop future leaders of cardiac imaging, emphasizing novel developmental and translational research. The training program, based in the MGH Cardiac MR-PET-CT Program, is a joint cardiology and radiology program, a model which greatly enhances opportunities for collaboration. The curriculum consists of didactic lectures including the clinical effectiveness course at the Harvard School of Public Health, laboratory exercises and individual research projects. A major strength of the Program is our outstanding faculty, each of whom are pursuing research at the cutting-edge of cardiac imaging science. The faculty consists of 21 MD and/or PhD scientists with expertise in cardiology, radiology, physics, computer science and outcomes research. Collectively they have over 50 active extramural grants and have supervised over 250 pre/post doctoral fellows in various aspects of basic and clinical cardiac imaging research. Extensive collaboration among the faculty, trainees, and accomplished investigators throughout the MGH, Harvard Medical School and MIT communities, further increase the Program's scientific impact. Broad exposure to highly motivated scientists and committed mentors, with an emphasis on individual scientific excellence, provide the conditions for the successful training of leaders in the use of these important technologies in cardiology. During the initial four years of NIH support, all NIH trainee positions were filled, and trainees authored or coauthored over 50 peer-reviewed publications. All finished trainees obtained staff positions in academic medical centers or continued in academic training programs. To enhance the program we have added technical faculty and novel equipment offering additional research opportunities for trainees in evolving areas of cardiac imaging science including FDG PET imaging of plaque activity, molecular imaging using optical and MR probes, 9.4T imaging of animal models, novel cardiac image reconstruction approaches and simultaneous imaging of stenosis and function during chemical stress using a dual source cardiac CT.