NATIONAL BIOMEDICAL COMPUTATION RESOURCE

NBCR的首要任务是通过利用最前沿的计算和信息技术来进行、催化和实现生物医学研究，并将重点放在转化性和多尺度研究上。在接下来的五年里，由于信息技术的持续革命和丰富的计算能力，我们看到了生物医学研究的巨大机遇。我们的目标是推进我们在多尺度生物医学方法方面的理解前沿；提供有意义的翻译成果；加快生物医学科学界对新兴信息技术的采用和发展；继续加强资源的多学科；并在翻译研究的关键领域创建合作者和用户的多学科社区。我们通过一系列相互关联的活动来实现这些目标：以透明的方式整合计算、数据和可视化资源，以便更好地访问分布式数据、计算资源、仪器和人员；开发和部署用于建模和仿真、三维图像处理以及交互式可视化的高级计算工具和包；为生物医学研究人员提供和支持先进的网络基础设施工具和环境。培养一批新的研究人员，使他们拥有实验生物学和与生物医学科学家相关的计算技术的跨学科实用知识。 在这次更新中，我们的核心技术研发活动将集中在三个主题上： 1.多尺度建模和可视化工具，用于数据精化、可视化工作流、 数学和可视化建模，可在适当的工具包和模拟包中找到。 2.目标生物医学和翻译的多尺度模拟软件包和流水线 研究以NBCR为基础，获得对关键生物医学过程和疾病的洞察 合作伙伴工具和利用网络基础设施。 3.灵活多变。可扩展的CvberInfrastructure框架，以解决采用和 针对当前和新兴的网络基础设施优化一些示范生物医学应用 同时确保科学的重现性。 这些发展是由翻译研究的合作项目推动的，并通过使用我们的工具的服务项目、关于我们的工具的培训和传播对社区产生更广泛的影响。

NBCR's overarching mission is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies, with a strong focus on translational and multiscale research. In the coming five years we see tremendous opportunities in biomedical research because of the continuing revolution in information technology and the abundance of computing availability. Our objectives are to advance the frontiers of our understanding in multiscale biomedical approaches; provide translational results of significance; accelerate the adoption and development of emerging information technologies by the, biomedical science community; continue to strengthen the multidisciplinarity of the resource; and create multidisciplinary communities of collaborators and users in key areas of translational research. We accomplish these goals through an interrelated set of activities: Integrate computational, data and visualization resources in a transparent way to enable better access to distributed data, computational resources, instruments and people; Develop and deploy advanced computational tools and packages for model building and simulation, three-dimensional image processing, and interactive visualization; Deliver and support advanced cyberinfrastructure tools and environments for biomedical researchers. Train a cadre of new researchers such that they have an interdisciplinary, working knowledge both of experimental biology and of computational technology relevant to biomedical scientists. In this renewal our core technology research and development activities will focus on three themes: 1. Multiscale Model Building and Visualization Tools, for data refinement, visual workflows, mathematical and visual modeling, available in appropriate toolkits and simulation packages. 2. Multiscale Simulation Software Packages and Pipelines for targeted biomedical and translational research to gain those insights into key biomedical processes and diseases, building on NBCR and partner tools and utilizing the cyberinfrastructure. 3. Flexible. Scalable Cvberinfrastructure Framework, to address practical issues of adopting and optimizing some exemplar biomedical applications to the current and emerging cyberinfrastructure while ensuring scientific reproducibility. These developments are driven by collaborative projects on translational research, and have broader impact on the community via service project that use our tools, training on our tools, and dissemination.