Improving patient outcomes in leukaemia by targeting cancer stem cells

血癌，如急性髓系白血病(AML)，是最致命的癌症类型之一，迫切需要新的治疗方法来提高这些疾病患者的存活率。AML致癌干细胞通过启动永生化计划存活下来，我们希望通过阻断这些关键途径来特异性地杀死这些AML干细胞。这包括控制细胞分裂方式和它们对基因损伤的反应方式的东西，以及其他新的途径。

Blood cancers such as acute myeloid leukaemia (AML) are among the most deadly types of cancer and new treatments are desperately needed to improve patient’s survival in these diseases. AML cancer-causing stem cells survive by turning on immortalization programs and we hope to specifically kill these AML stem cells by blocking these crucial pathways. This includes things that control the way the cells divide and the way they respond to genetic damage as well as other novel pathways.