Data Mangement and Statistics

数据管理和生物统计学核心的总体目标是：1）整合和管理数据 从不同的研究中心和许多类型（临床结果，实验室数据），允许研究者访问 并利用来自地球仪的安全存储数据，以及2）提供生物统计专业知识， 项目合作调查员和PIS在执行更复杂的分析以及咨询的行为 对于不太复杂的分析，核心PI（Friedman）、核心生物统计学家将满足核心目标 （Potts）和核心数据管理器（Twark）。弗里德曼博士将负责监督这些数据 单个项目和研究者的管理和生物统计需求。 该核心的主要目标之一是为所有项目提供数据管理专业知识和服务， investigators.具体而言，数据管理员和核心PI将设计基于Web的数据输入平台 屏幕，随附的病例报告表，并确保本网站和数据的安全。芯会 负责培训所有站点的数据输入人员，并监督和排除数据输入故障 问题.数据管理员将负责清理和合并来自不同来源的数据 包括人类实地研究的协变量和实验室产生的基本科学数据。数据 经理和核心Pl将负责向获得批准访问权限的研究者提供合并文件 通过这个网络平台。 Core的第二个目标是支持所有三个项目的数据分析活动， 强调项目1和项目2更复杂的数据分析需求。这些活动将由 核心PI（Friedman）并由PI和生物统计学家执行。在某些情况下，例如CART， 重复测量和ROC分析，核心将与项目合作执行分析 Pl和合作研究者。对于其他分析，核心将为Pis项目和合作研究者提供咨询 执行与其项目相关的分析。这包括正确的指导 这不仅是一种新的分析方法，也为更创新的分析方法提供了机会。

The overall objectives of the Data Management and Biostatistics Core are to 1) integrate and manage data from disparate sites and of many types (clinical outcomes, laboratory data) allowing investigators to access and utilize securely stored data from sites located across the globe and 2) provide biostatistical expertise for project co-investigators and Pis in the execution of more complex analyses as well as advice in the conduct of less complex analyses, he goals of the Core will be met by the Core PI (Friedman), Core Biostatistician (Potts), and Core Data Manager (Twark). Dr Friedman will be charged with overseeing the data management and biostatistical needs of individual projects and investigators. One of the main goals of this Core is to provide data management expertise and service to all projects and investigators. Specifically, the data manager and Core PI, will design the web-based platform with data entry screens, accompanying case report forms, and ensure the security of this site and data. The Core will be responsible for educating data entry personnel at all sites and overseeing and troubleshooting data entry issues. The data manager will be responsible for cleaning and merging data from disparate sources including covariates from human field studies and basic scientific data generated in the laboratory. The data manager and Core Pl will take responsibility for providing merged files to investigators with approved access through this web-based platform. The second goal of the Core is to support data analytic activities for all three projects, with particular emphasis on the more complex data analytic needs of Projects 1 and 2. These activities will be led by the core Pl (Friedman) and executed by both the PI and biostatistician. In some cases, for example CART, repeated measures, and ROC analyses, the Core will execute the analyses in collaboration with the project Pl and co-investigators. For other analyses, the Core will provide consultation to Project Pis and coinvestigators in the execution of analyses relevant to their projects. This includes guidance in the correct approach as well as providing opportunities for more innovative approaches to the analyses.