Training in Drug Abuse Related Research

描述（由申请人提供）：本申请是由路易斯赫什和琳达德沃斯基和沙龙沃尔什共同指导的培训计划的更新。我们要求继续支持四个博士前和两个博士后学员利用培训教师15住在三个学院和5个不同的部门在肯塔基州的大学。所有的培训教师都是通过NIDA资助的，或者与NIDA资助的培训教师合作，他们的研究主要集中在药物滥用的分子方面。肯塔基州大学在药物滥用研究方面有着悠久的历史，包括药物和酒精研究中心以及药物和酒精研究和翻译中心。这一培训方案的目标仍然是培养有前途的研究生和博士后研究员从事药物滥用研究工作。该计划提供药物滥用研究现代方面的广泛培训，特别强调研究参与药物反应的受体的细胞和分子方面，以及与这些受体相互作用的配体的发展，作为药物滥用的潜在药物治疗。培训教师在分子水平上理解与药物滥用有关的基本机制方面有着共同的兴趣。培训教师的重点集中在阿片受体配体的结构，阿片受体配体对生理过程的影响，以及阿片受体所涉及的蛋白质和配体的结构和功能。学员从一个强大的教师谁利用国家的最先进的方法来药物滥用研究学习。该计划的一个独特方面是学员与其他教师和学员参与药物滥用行为方面的互动，使他们对药物滥用研究有广泛的了解。希望这种独特的培训机会能够满足对药物滥用研究领域有广泛了解的新调查人员的需求。

DESCRIPTION ( provided by applicant): This application is for renewal of a training program directed by Louis Hersh and co-directed by Linda Dwoskin and Sharon Walsh. We request continued support for four predoctoral and two postdoctoral trainees utilizing a training faculty of 15 housed in three colleges and 5 different departments within the University of Kentucky. All of the training faculty have been funded through NIDA or collaborate with NIDA funding training faculty with their research broadly focused on the molecular aspects of drug abuse. The University of Kentucky has a long history of involvement in drug abuse research and includes the Center on Drug and Alcohol Research and the Center for Drug and Alcohol Research and Translation. The goal of this training program continues to be the preparation of promising graduate students and postdoctoral fellows for careers in drug abuse research. The program provides broad-based training in modern aspects of drug abuse research with a particular emphasis on studying the cellular and molecular aspects of receptors involved in the response to drugs and the development of ligands which interact with these receptors as potential pharmacotherapy's for drug abuse. The training faculty share a common interest in understanding basic mechanisms related to drug abuse at the molecular level. The emphasis of the training faculty focus on the structure of opiate receptor ligands, the effects of opiate receptor ligands on physiological processes, and the structure and function of the proteins and ligands involved in opiate receptors. Trainees learn from a strong faculty who utilize state-of-the-art methodological approaches to drug abuse research. A unique aspect of this program is the interaction of trainees with other faculty and trainees involved in the behavioral aspects of drug abuse, giving them a broad based understanding of drug abuse research. This unique training opportunity is hoped to fill the need for new investigators in drug abuse research who have a broad understanding of the field.