Contribution of circadian rhythm and maternal entrainment to infant regulation

描述(申请人提供)：生理节律是建立母婴之间互动同步性的核心，随后互动同步性是发展婴儿调节的基础。很少有研究将发育中的婴儿昼夜节律和母体夹带与母婴交互同步性和随后的婴儿调节联系起来。喂养困难，睡眠-觉醒模式被打乱，母婴相互作用改变是失调婴儿的特征。本研究的目的是刻画L婴儿昼夜节律发展的轨迹，检验母婴昼夜节律的早期同步性和交互作用，并基于节律和交互同步预测婴儿调节。主要目的包括：(1)确定母婴昼夜节律的时间和强度的纵向模式，通过在婴儿4、8和12周进行的活动记录的周期峰位、幅度和协方差拟合度(R2)来测量。(2)通过测定4、8、12周龄婴儿的唾液褪黑素昼夜节律，从纵向上探讨环境(光照、家庭常规)对昼夜节律的影响。(3)检查母婴生理同步性的纵向模式，定义为母婴昼夜节律(CR-Corr)参数(峰相、幅度和协方差匹配)之间的独立相关性，这些参数来自于婴儿4、8和12周的活动记录。(4)以母婴生理同步性(CR-Corr)为预测指标，评估母婴交互同步性(CO-ACT)的预测性，以12周时母婴协调凝视、发声和抚触的比例为指标，以婴幼儿症状自评量表(ITSC)、实验室气质评价组合(Lab-TAB)和简明婴儿睡眠问卷(BISQ)为预测因子，评估婴幼儿生理和情绪调节能力。40对健康母婴将采用纵向设计进行研究，测量时间分别为4周、8周、12周和32周。在4周、8周和12周时，将使用活动记录结合环境光测量来确定家中活动的昼夜节律，并将在24小时内连续采集唾液样本以评估褪黑素节律。在12周时，面对面情感同步(CO-ACT)将从母婴互动的5分钟视频记录中编码。在32周时，将使用实验室气质评估组合(Lab-TAB)、婴幼儿症状检查表(ITSC)和简明婴儿睡眠问卷(BISQ)评估婴儿的调节能力，并评估母亲的睡眠和觉醒障碍、抑郁、疲劳以及家庭日常生活。昼夜节律将由余弦分析得出。余弦参数(峰相位、幅度、余弦或拟合度)将相互关联(CR-Corr)。母婴生理同步性(CR-CORR)将被用来预测12周时的交互同步性和32周时的婴儿调节。

DESCRIPTION (provided by applicant): Physiological rhythm is central to establishment of interactive synchrony between mothers and infants and subsequently interactive synchrony is the foundation for development of infant regulation. Few studies have associated developing infant circadian rhythm and maternal entrainment with maternal-infant interactive synchrony and subsequent infant regulation. Feeding difficulties, disrupted sleep-wake pattern, and altered maternal-infant interaction are characteristic of dysregulated infants. The purpose of the proposed research is to characterize the l trajectory of infant circadian rhythm development, examine early synchrony of maternal and infant circadian rhythm and interaction, and predict infant regulation based on rhythm and interactive synchrony. Primary Aims include: (1) Determine the longitudinal pattern of maternal and infant circadian rhythm timing and strength as measured by cycle acrophase, amplitude, and cosinor fit (R2) of actigraphy recordings performed at 4, 8, and 12 weeks infant age. (2) Explore longitudinally environmental influences (light, home routine) on entrainment of circadian rhythm as measured by maternal and infant salivary melatonin circadian rhythm assessed at 4, 8, and 12 weeks infant age. (3) Examine the longitudinal pattern of maternal- infant physiological synchrony defined as the separate correlations between mother and infant circadian rhythm (CR-CORR) parameters (acrophase, amplitude, and cosinor fit) derived from actigraphy recordings performed at 4, 8, and 12 weeks infant age. (4) Assess the prediction of (a) maternal-infant interactional synchrony (CO-ACT), as measured by proportion of coordinated gaze, vocalization, and touch at 12 weeks, and (b) infant physiological and emotional regulation as measured by Infant/Toddler Symptom Checklist (ITSC), Laboratory Temperament Assessment Battery (Lab-TAB), and Brief Infant Sleep Questionnaire (BISQ) at 32 weeks infant age, using maternal-infant physiological synchrony (CR-CORR) as predictor. Forty healthy mother-infant pairs will be studied using a longitudinal design with times of measure at 4, 8, 12, and 32 weeks infant age. At 4, 8, and 12 weeks circadian rhythm of activity will be determined in the home using actigraphy recordings, combined with measurement of environmental light, and salivary samples will be collected serially throughout a 24-hour day to assess melatonin rhythm. At 12 weeks face-to-face affect synchrony (CO-ACT) will be coded from a 5 minute video recording of mother-infant interaction. At 32 weeks infant regulation will be assessed using the Laboratory Temperament Assessment Battery (Lab-TAB), Infant/Toddler Symptom Checklist (ITSC), and Brief Infant Sleep Questionnaire (BISQ) and maternal sleep and wake disturbance, depression, and fatigue as well as home routine will be assessed. Circadian rhythm will be derived from cosinor analysis. Cosinor parameters (acrophase, amplitude, cosinor fit) will be correlated (CR-CORR). Maternal-infant physiological synchrony (CR-CORR) will be used to predict interactive synchrony at 12 weeks and infant regulation at 32 weeks.