Translational Biology Core

核心B旨在通过标准化通用方法和资源为项目提供支持，确保整个计划项目的一致性和定量准确性。核心的每项服务都与每个项目相关，并将被每个项目利用。核心B的目标有六个方面： 具体目标1：为每个项目提供细胞系、培养基和采集血清的集中储存库。 具体目标2：使用临床前和临床放射治疗系统对小动物进行宽野和适形照射。 具体目标3：使用正电子发射断层扫描（PET）、X射线计算机断层扫描（CT）和生物发光成像（BLI）的临床前系统对小动物进行多模态成像。 具体目的4：对从实验动物模型中采集的组织标本进行组织病理学分析。 具体目标5：对通过其他具体目标收集的成像数据进行定量分析。 具体目标6：为P01项目提供统计支持。

Core B is designed to provide support to the projects by standardizing common methods and resources, ensuring consistency and quantitative accuracy across the Program Project. Each service of the Core is relevant to and will be utilized by each project. The goals of Core B are six fold: Specific Aim 1: To provide a centralized repository of cell lines, media, and collected serum for each project. Specific Aim 2: To perform wide-field and conformal irradiation of small animals using preclinical and clinical radiotherapy systems. Specific Aim 3: To perform multimodal imaging of small animals using preclinical systems for positron emission tomography (PET), x-ray computed tomography (CT), and bioluminescence imaging (BLI). Specific Aim 4: To perform histopathologic analysis of tissue specimens collected from experimental animal models. Specific Aim 5: To perform quantitative analysis of imaging data collected through the other Specific Aims. Specific Aim 6: To provide statistical support to the projects of the P01.