Biostatistic/Outcomes Cores

异基因造血干细胞移植(HSCT)是许多恶性血液病和骨髓衰竭患者的唯一治疗方法。移植成功的一个关键障碍是移植物抗宿主病(GVHD)。在这一新的应用中，研究项目的最终目的是进一步提高我们对aGVHD和cGVHD的病理生理学的理解，并通过在维持GVL的同时针对这两种综合征中不同的细胞群来开发预防和治疗cGVHD的新策略。实现这一目标的关键，从而导致 该方案项目的成功是与3个项目和其他3个核心中的每个项目中的个人进行动态生物统计学合作。 生物统计核心C的目的是提供以下服务，这些服务将被本计划项目中包括的研究项目所利用。 1.为转译临床研究提供生物统计学协作。 2.为转译动物研究提供生物统计学合作。 3.为转化性实验室研究提供生物统计和/或生物信息学合作。 4.为翻译研究提供研究基础。 5.为数据处理、统计分析、标准化报告和质量控制提供计算资源。

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for many patients with hematologic malignancies and marrow failure. A critical hurdle in accomplishment of successful HSCT has been graft-versus-host disease (GVHD).The ultimate objective of the research projects in this renewal application is to further improve our understanding of the pathophysiology of aGVHD and cGVHD and to develop novel strategies for both prevention and therapy of cGVHD by targeting distinct cellular populations in these two syndromes while maintaining GVL. Key to achieve this objective and thus to lead to the success of this program project is dynamic biostatistical collaboration with individuals in each of the 3 projects and the 3 other Cores. The purpose of the Biostatistics Core C is to provide the following services that will be utilized by the research projects included in this Program Project. 1. To provide biostatistical collaboration for translational clinical research studies. 2. To provide biostatistical collaboration for translational animal research studies. 3. To provide biostatistical and/or bioinformatics collaboration for translational laboratory research studies. 4. To provide research infrastructure for translational research. 5. To provide computing resources for data processing, and statistical analysis, standardized reporting, and quality control.