2014 Cellular and Molecular Bioengineering (CMBE) Conference

描述（由申请人提供）：本申请的目标是为2014年细胞和分子生物工程（CMBE）会议的学生/研究员和年轻独立研究人员（新星）寻求旅行奖励资金。 会议的主题是“多尺度机械生物学：从形态发生到核机械转导”。 我们对机械扰动在生命的各个方面所起作用的理解不断扩大，从形态发生到染色质重塑， 推动了这次会议的使命。 此外，细胞和分子生物工程技术使我们能够在分子水平和跨长度尺度上探测甚至控制细胞活性和微环境，从而实现细胞生物学，药物发现和再生的新基础研究。我们计划召开一次工程师和生物学家的会议，以鼓励为实现这些共同目标而分享想法。我们选择的主题是为了解决理解机械扰动如何转化为细胞活动变化的关键问题，从生物体到核水平。 这 这些问题不能仅靠传统的策略来解决，这些新的方向将塑造CMBE的未来。 R13应用的具体目标有两个方面。 第一个是为初级研究人员、博士后研究员和研究生提供支持，他们提交的论文根据科学价值被选上讲台，并促进该领域代表性不足的群体和妇女。会议将为长期跨学科互动的发展提供一个平台，并使生物工程，生物学和医学的研究人员接触到CMBE汇合处的最新想法和机会。R13应用程序的第二个目标是促进CMBE新兴子领域的出现和发展。这次CMBE会议的具体目标是：目标#1：建立跨长度尺度的机械生物学的现状，从生物体到核机械生物学。 受邀的领导人将通过概述他们的工作来解决从分子到生物工程方法的这一总体主题，特别强调跨尺度的分子/细胞/组织功能。 目标二：头脑风暴在CMBE研究的知识和问题领域的差距，重点是规模在理解细胞/分子力学，运动，ECM功能，组织和器官形成的作用。这将为我们的组织以及广大的CMBE社区提供关于CMBE领域的未来方向和指导方针和蓝图。 会议的成果将发表在BMES杂志细胞和分子生物工程的特刊上。

DESCRIPTION (provided by applicant): The goal of this application is to seek funding for travel awards for students/fellows and young independent investigators (Rising Stars) for the 2014 Cellular and Molecular Bioengineering (CMBE) Conference. The specific theme of the conference is 'Multi-scale Mechanobiology: From Morphogenesis to Nuclear Mechanotransduction'. Our expanding understanding of the role that mechanical perturbations play in every aspect of life, from morphogenesis to chromatin remodeling, motivated the mission of this conference. Moreover, cell and molecular bioengineering technologies that allow us to probe and even control cell activity and the microenvironment at the molecular level and across length scales enables new fundamental studies in cell biology, drug discovery, and regeneration. We have planned a conference integrating both engineers and biologists to encourage sharing of ideas toward these common goals. Our choice of theme is intended to address the key problem of understanding how mechanical perturbations translate to changes in cellular activity, from the organismal to nuclear level. This problem cannot be solved by traditional strategies alone, and these new directions will shape the future of CMBE. The specific objectives of this R13 application are two-fold. The first i to provide support to junior investigators, postdoctoral fellows and graduate students whose submitted papers have been selected for podium presentation on the basis of scientific merit, and to promote underrepresented groups and women in the field. The meeting will provide a platform for the development of long-term interdisciplinary interactions, and expose researchers in bioengineering, biology, and medicine to the latest ideas and opportunitis at the confluence of CMBE. The second objective of this R13 application is to foster the emergence and growth of the burgeoning sub-field of CMBE. The specific aims of this CMBE Conference are: Aim #1: Establish the current status of mechanobiology across length scales, from organismal to nuclear mechanobiology. Invited leaders will address this overarching theme from molecular to bioengineering approaches via an overview of their work, with a special emphasis on molecular/cellular/tissue functions across scales. Aim #2: Brainstorm gaps in knowledge and problem areas in CMBE research with a focus on the role of scale in understanding cellular/molecular mechanics, motility, ECM function, and tissue and organ formation. This will provide keystone future directions regarding the field of CMBE and guidelines and blueprints for the CMBE field to our organizations, and in general, to the broad CMBE community. The outcomes of the conference will be published in a special issue of the BMES journal Cellular and Molecular Bioengineering.