Center for Genomic Studies on Mental Disorders

描述(由申请人提供)：NIMH人类遗传学倡议(HGI)的目标是进一步了解精神障碍的遗传和环境病因。实现这一目标的主要机制之一是NIMH精神疾病合作基因组研究中心(“中心”)，该中心接收来自NIMH PI的原始生物样本，如血液。该中心将样本处理成DNA、RNA、cDNA或细胞系，然后提交进行基因组分析。除了生物样本，该中心还接收每个受试者的临床/表型数据，并最终获得基因组分析的结果。经过一段时间的专利后，所有NIMH批准的研究人员都可以通过安全网站获得临床数据、基因组数据、DNA、RNA、cDNA和细胞系。这种来自许多队列的统一处理的生物样本以及临床和基因组数据的共享利用了NIMH对大量HGI赠款的投资。它提供了大量适用于个体精神障碍遗传基础调查的数据，从而提供了关键的研究力量。自1998年10月以来，已提交了147,000份样本，该中心已分发了31,000份DNA样本和9,000株细胞系。使用这些样本和数据，已经有&gt；450份临床和基因数据分发给了340名研究人员和&gt；260份出版物。从2011年开始，该中心为诱导多能干细胞(IPSC)及其祖细胞体细胞提供细胞系储存和鉴定服务。该中心还开发了新的生物信息学和计算基因组学工具和方法，旨在整合和分析大量独立的基因和表型数据，同时解决数据集中的表型和/或基因差异。中心将以不断创新为指导宗旨，服务于科学研究 以灵活和高度可访问的方式满足NIMH PI的需求，同时尊重主体机密性、知情同意问题和PI特权。

DESCRIPTION (provided by applicant): The goal of the NIMH Human Genetics Initiative (HGI) is to further understand the genetic and environmental etiologies of mental disorders. One of the major mechanisms for accomplishing this goal is the NIMH Center for Collaborative Genomics Research on Mental Disorders (the "Center"), which receives raw biosamples such as blood from NIMH PIs. The Center processes samples to DNA, RNA, cDNA or cell lines, which can then be submitted for genomic analyses. Along with biosamples the Center receives clinical/phenotypic data for each subject and, eventually, the results of genomic analyses. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA and cell lines are made available to all NIMH-approved researchers through a. secure web site. This sharing of uniformly processed biological samples and clinical and genomic data from many cohorts leverages the NIMH investment in a large number of HGI grants. It provides critical research power by providing a large body of data applicable to investigations on the genetic bases for individual mental disorders. Since October 1998, >147,000 subject samples have been submitted and the Center has distributed >310,000 DNA samples and >9,000 cell lines. There have been >450 distributions of clinical and genotype data to ~340 investigators and >260 publications using these samples and data. Starting in 2011 the Center provided cell line banking and characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells. The Center also develops novel bioinformatics and computational genomics tools and methodologies designed to integrate and analyze large, independent sets of genotypic and phenotypic data while resolving phenotype and/or genotype discrepancies in datasets. As its guiding aim, the Center will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues and PI prerogatives.