Development and Maintenance ofa MUltigenotypic Aged Mouse Colony

培养、维持和分配一群具有遗传特征的老龄实验室小鼠，供研究人员在衰老研究中使用。这个群体将在受控和明确的屏障环境中发展和维护，在这种环境中，动物受到监测并确定疾病状态和遗传纯度的标志。目前和计划使用啮齿动物来模拟人类的衰老过程和与年龄相关的疾病的实验要求动物具有明确的基因型和受控的环境和健康状态。只有对遗传和环境变量进行细致、长期的控制，才有可能维持相关的动物模型，这些模型可能用于研究衰老过程中的许多生物和行为过程。因此，源源不断地提供基因明确、特性良好的近亲繁殖和杂交实验动物对于衰老研究项目至关重要。

To develop, maintain and distribute a standing colony of aged, genetically defined laboratory mice for use by investigators in studies of aging. This colony is to be developed and maintained within controlled and defined barrier environments where animals are monitored and characterized for disease status and markers of genetic purity. Current and projected experiments using rodents to model the aging processes and age-related diseases in humans require animals of defined genotype and controlled environmental and health status. Only with the meticulous, long-term control of genetic and environmental variables is it possible to maintain relevant animal models that may be used to study many of the biological and behavioral processes in aging. Therefore, a continuous supply of genetically defined, well characterized inbred and hybrid laboratory animals is essential for a program of research on aging.