The Chemistry-Biology Interface Program at Johns Hopkins University

描述（由申请人提供）：本提案旨在重新支持约翰霍普金斯大学化学生物学接口（CBI）的培训计划，该计划成立于2005年，并于2008年获得NIH的支持。其目标是培养博士前学生使用化学和生物学的工具进行生物医学研究。该计划是生物化学和分子生物学系教师之间的合作努力（彭博公共卫生学院），药理学和分子科学（医学院），生物物理学和生物物理化学（医学院），化学和生物分子工程（怀汀工程学院），与他们的同事在生物学，生物物理学和化学部门（艺术与科学的Zanvyl Krieger学校）。学生参与者有各种各样的研究项目，包括合成，机理，酶学，分子成像和生物大分子结构，可从32个研究小组中选择。学生接受生物和化学科学的课程培训，包括专门为该计划设计的化学生物学两个学期的课程，但对所有约翰霍普金斯大学的学生开放。CBI计划的其他方面包括CBI论坛，学生在那里提出原创研究提案，研究更新，第一年的研究轮换结果，并捍卫他们的论文，以及年度务虚会。 学生们沉浸在一个共同的课程（独立于他们的研究顾问持有主要任命的部门），直接申请到CBI计划，并获得博士学位。化学生物学在完成后 CBI计划于2005年秋季启动，使用大学的资金，继续提供高水平的支持。NIH目前为5名学生提供一年的支持。需要为6名研究生提供支助。一个广泛的支持网络，以咨询和指导的形式，以最大限度地提高学生的成功。这导致自2005年该方案开始以来，学生的保留率超过92%。

DESCRIPTION (provided by applicant): This proposal seeks to renew support for a training program at the Chemistry-Biology Interface (CBI) at Johns Hopkins University that was established in 2005 and received NIH support in 2008. The goal is to train predoctoral students to carry out biomedical research using the tools of Chemistry and Biology. The Program is a collaborative effort between faculty in the Departments of Biochemistry and Molecular Biology (Bloomberg School of Public Health), Pharmacology and Molecular Sciences (School of Medicine), Biophysics and Biophysical Chemistry (School of Medicine), and Chemical and Biomolecular Engineering (Whiting School of Engineering), with their colleagues in the Biology, Biophysics, and Chemistry Departments (Zanvyl Krieger School of Arts & Sciences). Student participants have a diverse array of research projects including synthesis, mechanism, enzymology, molecular imaging, and biomacromolecular structure to choose from in 32 research groups. The students receive coursework training in the biological and chemical sciences, including a two-semester course in Chemical Biology designed especially for the Program, but open to all Johns Hopkins University students. Other aspects of the CBI Program include CBI Forum where students present original research proposals, research updates, first year research rotation results, and defend their theses, as well as an Annual Retreat. The students are immersed in a common curriculum (independent of the Department in which their research advisors hold primary appointments), apply directly to the CBI Program, and receive a Ph.D. in Chemical Biology upon completion. The CBI Program was initiated in fall 2005 using funding from the University, which continues to provide a high level of support. NIH currently provides one year of support for 5 students. Support is requested for 6 graduate students. An extensive network of support in the form of advising and mentoring is in place to maximize the students' success. This has resulted in >92% retention of students since the program began in 2005.